dc.contributor.author	Wibowo, Anjar
dc.contributor.author	Becker, Claude
dc.contributor.author	Marconi, Gianpiero
dc.contributor.author	Durr, Julius
dc.contributor.author	Price, Jonathan
dc.contributor.author	Hagmann, Jorg
dc.contributor.author	Papareddy, Ranjith
dc.contributor.author	Putra, Hadi
dc.contributor.author	Kageyama, Jorge
dc.contributor.author	Becker, Jorg
dc.contributor.author	Weigel, Detlef
dc.contributor.author	Gutierrez-Marcos, Jose
dc.date.accessioned	2016-06-08T12:26:45Z
dc.date.available	2016-06-08T12:26:45Z
dc.date.issued	2016-05-31
dc.description.abstract	Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal 'short-term stress memory' with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring.	pt_PT
dc.description.sponsorship	Royal Society grant: (IE150496); ESF/RTD Framework COST action: (FA0903); Biotechnology and Biological Sciences Research Council grant: (BB/F008082); Deutsche Forschungsgemeinschaft grant: (SFB 1101 - Project C01); Max-Planck-Gesellschaft; ERA-CAPs project: (EVOREPRO).	pt_PT
dc.identifier.citation	eLife 2016;5:e13546	pt_PT
dc.identifier.doi	10.7554/eLife.13546	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/629
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Elife Sciences Publications	pt_PT
dc.relation	Aquired Environmental Epigenetics Advances: from Arabidopsis to maize
dc.relation.publisherversion	https://elifesciences.org/content/5/e13546	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	DNA	pt_PT
dc.subject	memory	pt_PT
dc.subject	genome	pt_PT
dc.subject	adaptation	pt_PT
dc.subject	Arabidopsis	pt_PT
dc.subject	Hyperosmotic stress	pt_PT
dc.subject	epigenetic	pt_PT
dc.title	Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Aquired Environmental Epigenetics Advances: from Arabidopsis to maize
oaire.awardURI	info:eu-repo/grantAgreement/EC/FP7/226477/EU
oaire.citation.endPage	27	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	eLife	pt_PT
oaire.citation.volume	5	pt_PT
oaire.fundingStream	FP7
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.name	European Commission
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	1ab72dbe-0087-4f21-b405-0f61f57901e8
relation.isProjectOfPublication.latestForDiscovery	1ab72dbe-0087-4f21-b405-0f61f57901e8

Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity

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