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A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster

2016-07-01Journal article Open access
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dc.contributor.authorPimenta-Marques, A.
dc.contributor.authorBento, I.
dc.contributor.authorLopes, C. A. M.
dc.contributor.authorDuarte, P.
dc.contributor.authorJana, S. C.
dc.contributor.authorBettencourt-Dias, M.
dc.date.accessioned2018-02-21T16:56:07Z
dc.date.available2018-02-21T16:56:07Z
dc.date.issued2016-07-01
dc.descriptionThe deposited article is a post-print version and has been submitted to peer review.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed by the main article plus the supplementary materials of the publication.pt_PT
dc.description.abstractAn important feature of fertilization is the asymmetric inheritance of centrioles. In most species it is the sperm that contributes the initial centriole, which builds the first centrosome that is essential for early development. However, given that centrioles are thought to be exceptionally stable structures, the mechanism behind centriole disappearance in the female germ line remains elusive and paradoxical. We elucidated a program for centriole maintenance in fruit flies, led by Polo kinase and the pericentriolar matrix (PCM): The PCM is down-regulated in the female germ line during oogenesis, which results in centriole loss. Perturbing this program prevents centriole loss, leading to abnormal meiotic and mitotic divisions, and thus to female sterility. This mechanism challenges the view that centrioles are intrinsically stable structures and reveals general functions for Polo kinase and the PCM in centriole maintenance. We propose that regulation of this maintenance program is essential for successful sexual reproduction and defines centriole life span in different tissues in homeostasis and disease, thereby shaping the cytoskeleton.pt_PT
dc.description.sponsorshipFundação Para a Ciência e Tecnologia grants: (SFRH/BD/33565/2008, SFRH/BPD/79680/2011, SFRH/BPD/87479/2012, PTDC/SAU-BD/105616/2008); Ciencia2007; EMBO Installation grant; ERC grant: (ERC-2010-StG-261344).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationA. Pimenta-Marques et al ., Science 353 , aaf4866 (2016). DOI: 10.1126/science.aaf486pt_PT
dc.identifier.doi10.1126/science.aaf4866pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/842
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relationHOW TO ACHIEVE THE PERFECT NUMBER REGULATION OF THE NOVO FORMATION AND CENTROSOME INACTIVATION
dc.relationControl of Centriole Structure And Number
dc.relation.publisherversionhttp://science.sciencemag.org/content/353/6294/aaf4866pt_PT
dc.subjectAnimalspt_PT
dc.subjectCentriolespt_PT
dc.subjectDrosophila Proteinspt_PT
dc.subjectFemalept_PT
dc.subjectFertilizationpt_PT
dc.subjectGene Deletionpt_PT
dc.subjectMicrotubulespt_PT
dc.subjectOocytespt_PT
dc.subjectOvumpt_PT
dc.subjectProtein-Serine-Threonine Kinasespt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectOogenesispt_PT
dc.titleA mechanism for the elimination of the female gamete centrosome in Drosophila melanogasterpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHOW TO ACHIEVE THE PERFECT NUMBER REGULATION OF THE NOVO FORMATION AND CENTROSOME INACTIVATION
oaire.awardTitleControl of Centriole Structure And Number
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F33565%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F79680%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F87479%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F105616%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/261344/EU
oaire.citation.endPageaaf4866-10pt_PT
oaire.citation.issue6294pt_PT
oaire.citation.startPageaaf4866-1pt_PT
oaire.citation.titleSciencept_PT
oaire.citation.volume353pt_PT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication0d25f60d-5934-4dd9-a87e-16a4a02d5387
relation.isProjectOfPublication1b42a6c4-68f1-4be3-9490-99fdbbb7e975
relation.isProjectOfPublication12b42d08-d406-470c-a972-2ac4992a9b3e
relation.isProjectOfPublication1848efe2-6ac0-4b9c-a402-c3138611e8d1
relation.isProjectOfPublication0faa6bb2-99b3-4582-9b24-873d528eceb3
relation.isProjectOfPublication.latestForDiscovery1b42a6c4-68f1-4be3-9490-99fdbbb7e975

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