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Nonequilibrium model for estimating parameters of deleterious mutations
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Autores
Orientador(es)
Resumo(s)
Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.
Descrição
Palavras-chave
Evolution Genetic Variation/genetics Genetics, Population/methods Models, Genetic Mutation/genetics Population Dynamics Selection, Genetic
Contexto Educativo
Citação
Gordo, I., Dionisio, F. (2005). Nonequilibrium model for estimating parameters of deleterious mutations. Phys. Rev. E. 71(3), 031907
Editora
American Physical Society