Nonequilibrium model for estimating parameters of deleterious mutations

Gordo, I.; Dionisio, F.

http://hdl.handle.net/10400.7/91

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Gordo,I._Phys.Rev._ (2005).pdf	main article	104.85 KB	Adobe PDF	Download

Send Feedback

Authors

Gordo, I.

Dionisio, F.

Abstract(s)

Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.