dc.contributor.author	Fransén-Pettersson, Nina
dc.contributor.author	Duarte, Nadia
dc.contributor.author	Nilsson, Julia
dc.contributor.author	Lundholm, Marie
dc.contributor.author	Mayans, Sofia
dc.contributor.author	Larefalk, Åsa
dc.contributor.author	Hannibal, Tine D
dc.contributor.author	Hansen, Lisbeth
dc.contributor.author	Schmidt-Christensen, Anja
dc.contributor.author	Ivars, Fredrik
dc.contributor.author	Cardell, Susanna
dc.contributor.author	Palmqvist, Richard
dc.contributor.author	Rozell, Björn
dc.contributor.author	Holmberg, Dan
dc.date.accessioned	2016-08-11T14:54:58Z
dc.date.available	2016-08-11T14:54:58Z
dc.date.issued	2016-07-21
dc.description	This deposit is composed by the main article plus the supplementary materials of the publication.
dc.description.abstract	Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from unaffected syngeneic donors can inhibit the disease phenotype. Because of the fibrotic component, early on-set, spontaneous nature and reproducibility, this novel mouse model provides a unique tool to gain further insight into the underlying mechanisms mediating transformation of chronic inflammation into fibrosis and to evaluate intervention protocols for treating conditions of fibrotic disorders.	pt_PT
dc.description.sponsorship	Vetenskapsrådet (VR) grant: (K2013-67X-07929- 27-3).	pt_PT
dc.identifier.citation	Fransén-Pettersson N, Duarte N, Nilsson J, Lundholm M, Mayans S, Larefalk Å, et al. (2016) A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis. PLoS ONE 11(7): e0159850. doi:10.1371/journal.pone.0159850	pt_PT
dc.identifier.doi	10.1371/journal.pone.0159850	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/683
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Plos	pt_PT
dc.relation.publisherversion	http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159850	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Mouse models	pt_PT
dc.subject	Fibrosis	pt_PT
dc.subject	Genetically modified animals	pt_PT
dc.subject	Cytokines	pt_PT
dc.subject	Inflammation	pt_PT
dc.subject	T cells	pt_PT
dc.subject	Inflammatory diseases	pt_PT
dc.subject	Spleen	pt_PT
dc.title	A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	14	pt_PT
oaire.citation.issue	7	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.volume	11	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT

A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis

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