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Genetic recombination and molecular evolution

2009Journal article Open access
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dc.contributor.authorCharlesworth, B.
dc.contributor.authorBetancourt, A.J.
dc.contributor.authorKaiser, V.B.
dc.contributor.authorGordo, I.
dc.date.accessioned2009-09-29T14:52:50Z
dc.date.available2009-09-29T14:52:50Z
dc.date.issued2009
dc.description.abstractReduced rates of genetic recombination are often associated with reduced genetic variability and levels of adaptation. Several different evolutionary processes, collectively known as Hill–Robertson (HR) effects, have been proposed as causes of these correlates of recombination. Here, we use DNA sequence polymorphism and divergence data from the noncrossing over dot chromosome of Drosophila to discriminate between two of the major forms of HR effects: selective sweeps and background selection. This chromosome shows reduced levels of silent variability and reduced effectiveness of selection. We show that neither model fits the data on variability. We propose that, in large genomic regions with restricted recombination, HR effects among nonsynonymous mutations undermine the effective strength of selection, so that their background selection effects are weakened. This modified model fits the data on variability and also explains why variability in very large nonrecombining genomes is not completely wiped out. We also show that HR effects of this type can produce an individual selection advantage to recombination, as well as greatly reduce the mean fitness of nonrecombining genomes and genomic regionspt
dc.identifier.citationCharlesworth B, Betancourt AJ, Kaiser VB, Gordo I. (2009). "Genetic recombination and molecular evolution". Cold Spring Harb Symp Quant Biol.Sep 4.pt
dc.identifier.issn1943-4456
dc.identifier.urihttp://hdl.handle.net/10400.7/31
dc.language.isoengpt
dc.relation.publisherversionhttp://dx.doi.org/10.1101/sqb.2009.74.015 sqb.2009.74.015
dc.titleGenetic recombination and molecular evolutionpt
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt
rcaap.typearticlept

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