Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here, we aimed to determine the impact of Mcc deletion on the cellular pathways and carcinogenesis associated with inflammation in the mouse proximal colon.

Keywords

Animals Cadherins Colon Colorectal Neoplasms DNA Repair Disease Models, Animal Down-Regulation Female GTP Phosphohydrolases Gene Expression Regulation, Neoplastic Inflammation Interferon-gamma Male Mice, Inbred C57BL Mice, Knockout Up-Regulation beta Catenin Gene Deletion Genes, MCC