Publication
Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer
| dc.contributor.author | Currey, Nicola | |
| dc.contributor.author | Jahan, Zeenat | |
| dc.contributor.author | Caldon, C. Elizabeth | |
| dc.contributor.author | Tran, Phuong N. | |
| dc.contributor.author | Benthani, Fahad | |
| dc.contributor.author | De Lacavalerie, Penelope | |
| dc.contributor.author | Roden, Daniel L. | |
| dc.contributor.author | Gloss, Brian S. | |
| dc.contributor.author | Campos, Claudia | |
| dc.contributor.author | Bean, Elaine G. | |
| dc.contributor.author | Bullman, Amanda | |
| dc.contributor.author | Reibe-Pal, Saskia | |
| dc.contributor.author | Dinger, Marcel E. | |
| dc.contributor.author | Febbraio, Mark A. | |
| dc.contributor.author | Clarke, Stephen J. | |
| dc.contributor.author | Dahlstrom, Jane E. | |
| dc.contributor.author | Kohonen-Corish, Maija R.J. | |
| dc.date.accessioned | 2021-01-05T09:47:34Z | |
| dc.date.available | 2021-01-05T09:47:34Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here, we aimed to determine the impact of Mcc deletion on the cellular pathways and carcinogenesis associated with inflammation in the mouse proximal colon. | pt_PT |
| dc.description.sponsorship | Fundação Calouste Gulbenkian | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.jcmgh.2019.01.009 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.7/962 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Animals | pt_PT |
| dc.subject | Cadherins | pt_PT |
| dc.subject | Colon | pt_PT |
| dc.subject | Colorectal Neoplasms | pt_PT |
| dc.subject | DNA Repair | pt_PT |
| dc.subject | Disease Models, Animal | pt_PT |
| dc.subject | Down-Regulation | pt_PT |
| dc.subject | Female | pt_PT |
| dc.subject | GTP Phosphohydrolases | pt_PT |
| dc.subject | Gene Expression Regulation, Neoplastic | pt_PT |
| dc.subject | Inflammation | pt_PT |
| dc.subject | Interferon-gamma | pt_PT |
| dc.subject | Male | pt_PT |
| dc.subject | Mice, Inbred C57BL | pt_PT |
| dc.subject | Mice, Knockout | pt_PT |
| dc.subject | Up-Regulation | pt_PT |
| dc.subject | beta Catenin | pt_PT |
| dc.subject | Gene Deletion | pt_PT |
| dc.subject | Genes, MCC | pt_PT |
| dc.title | Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 839 | pt_PT |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.startPage | 819 | pt_PT |
| oaire.citation.title | Cellular and Molecular Gastroenterology and Hepatology | pt_PT |
| oaire.citation.volume | 7 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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