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Publication
Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
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Advisor(s)
Abstract(s)
Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.
Description
Keywords
Animals Bone Development Fibroblast Growth Factors Homeodomain Proteins Mice Mice, Transgenic Models, Biological Models, Genetic Muscle Development Myogenic Regulatory Factor 5 Myogenic Regulatory Factors Phenotype Platelet-Derived Growth Factor Gene Expression Regulation, Developmental
Citation
Tânia Vinagre, Natalia Moncaut, Marta Carapuço, Ana Nóvoa, Joana Bom, Moisés Mallo, Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains, Developmental Cell, Volume 18, Issue 4, 20 April 2010, Pages 655-661, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2010.02.011.