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Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
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Orientador(es)
Resumo(s)
Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.
Descrição
Palavras-chave
Animals Bone Development Fibroblast Growth Factors Homeodomain Proteins Mice Mice, Transgenic Models, Biological Models, Genetic Muscle Development Myogenic Regulatory Factor 5 Myogenic Regulatory Factors Phenotype Platelet-Derived Growth Factor Gene Expression Regulation, Developmental
Contexto Educativo
Citação
Tânia Vinagre, Natalia Moncaut, Marta Carapuço, Ana Nóvoa, Joana Bom, Moisés Mallo, Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains, Developmental Cell, Volume 18, Issue 4, 20 April 2010, Pages 655-661, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2010.02.011.
Editora
Cell Press