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Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains

2010-04-20Journal article Open access
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dc.contributor.authorVinagre, Tânia
dc.contributor.authorMoncaut, Natalia
dc.contributor.authorCarapuço, Marta
dc.contributor.authorNóvoa, Ana
dc.contributor.authorBom, Joana
dc.contributor.authorMallo, Moisés
dc.date.accessioned2016-06-28T15:30:11Z
dc.date.available2016-06-28T15:30:11Z
dc.date.issued2010-04-20
dc.description.abstractHox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (PTDC/BIA-BCM/71619/2006, POCTI-ISFL-4-664, SFRH/BD/27306/2006, SFRH/BPD/26668/2006).pt_PT
dc.identifier.citationTânia Vinagre, Natalia Moncaut, Marta Carapuço, Ana Nóvoa, Joana Bom, Moisés Mallo, Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains, Developmental Cell, Volume 18, Issue 4, 20 April 2010, Pages 655-661, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2010.02.011.pt_PT
dc.identifier.doi10.1016/j.devcel.2010.02.011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/669
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1534580710001097pt_PT
dc.subjectAnimalspt_PT
dc.subjectBone Developmentpt_PT
dc.subjectFibroblast Growth Factorspt_PT
dc.subjectHomeodomain Proteinspt_PT
dc.subjectMicept_PT
dc.subjectMice, Transgenicpt_PT
dc.subjectModels, Biologicalpt_PT
dc.subjectModels, Geneticpt_PT
dc.subjectMuscle Developmentpt_PT
dc.subjectMyogenic Regulatory Factor 5pt_PT
dc.subjectMyogenic Regulatory Factorspt_PT
dc.subjectPhenotypept_PT
dc.subjectPlatelet-Derived Growth Factorpt_PT
dc.subjectGene Expression Regulation, Developmentalpt_PT
dc.titleEvidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domainspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage661pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage655pt_PT
oaire.citation.titleDevelopmental Cellpt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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