Repository logo
 
Publication

Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

2015-03-24Journal article Open access
Simple item page
dc.contributor.authorThompson, Jessica Ann
dc.contributor.authorOliveira, Rita Almeida
dc.contributor.authorDjukovic, Ana
dc.contributor.authorUbeda, Carles
dc.contributor.authorXavier, Karina Bivar
dc.date.accessioned2016-06-21T14:06:27Z
dc.date.available2016-06-21T14:06:27Z
dc.date.issued2015-03-24
dc.description.abstractThe mammalian gut microbiota harbors a diverse ecosystem where hundreds of bacterial species interact with each other and their host. Given that bacteria use signals to communicate and regulate group behaviors (quorum sensing), we asked whether such communication between different commensal species can influence the interactions occurring in this environment. We engineered the enteric bacterium, Escherichia coli, to manipulate the levels of the interspecies quorum sensing signal, autoinducer-2 (AI-2), in the mouse intestine and investigated the effect upon antibiotic-induced gut microbiota dysbiosis. E. coli that increased intestinal AI-2 levels altered the composition of the antibiotic-treated gut microbiota, favoring the expansion of the Firmicutes phylum. This significantly increased the Firmicutes/Bacteroidetes ratio, to oppose the strong effect of the antibiotic, which had almost cleared the Firmicutes. This demonstrates that AI-2 levels influence the abundance of the major phyla of the gut microbiota, the balance of which is known to influence human health.pt_PT
dc.description.sponsorshipHoward Hughes Medical Institute grants: (International Early Career Scientist, HHMI 55007436); Fundação para a Ciência e Tecnologia grants: (PTDC/BIA-EVF/118075/2010, RECI/IMI-IMU/0038/2012); Ministerio de Ciencia e Innovacion grants: (MICINN, SAF2011-29458).pt_PT
dc.identifier.citationJessica Ann Thompson, Rita Almeida Oliveira, Ana Djukovic, Carles Ubeda, Karina Bivar Xavier, Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota, Cell Reports, Volume 10, Issue 11, 24 March 2015, Pages 1861-1871, ISSN 2211-1247, http://dx.doi.org/10.1016/j.celrep.2015.02.049. (http://www.sciencedirect.com/science/article/pii/S2211124715002077)pt_PT
dc.identifier.doi10.1016/j.celrep.2015.02.049pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/658
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.relationROLE OF THE MICROBIOTA IN THE DEFENSE AGAINST ANTIBIOTIC RESISTANT PATHOGENS
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S2211124715002077pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectBacteroidetespt_PT
dc.subjectEscherichia colipt_PT
dc.subjectHomoserinept_PT
dc.subjectIntestinespt_PT
dc.subjectLactonespt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectMicrobiotapt_PT
dc.subjectStaphylococcaceaept_PT
dc.subjectStreptomycinpt_PT
dc.subjectQuorum Sensingpt_PT
dc.titleManipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiotapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleROLE OF THE MICROBIOTA IN THE DEFENSE AGAINST ANTIBIOTIC RESISTANT PATHOGENS
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/293894/EU
oaire.citation.endPage1871pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1861pt_PT
oaire.citation.titleCell Reportspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication807b1dc0-0af3-4e09-9142-0e8cb568ac76
relation.isProjectOfPublication.latestForDiscovery807b1dc0-0af3-4e09-9142-0e8cb568ac76

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1-s2.0-S2211124715002077-main.pdf
Size:
2.15 MB
Format:
Adobe Portable Document Format
Description:
artigo principal
Download
Thumbnail Image
Name:
mmc1(1).pdf
Size:
2 MB
Format:
Adobe Portable Document Format
Description:
material suplementar 1
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CD- Artigos