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Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family

2015-03-04Journal article Open access
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dc.contributor.authorTanaka, Kohtaro
dc.contributor.authorDiekmann, Yoan
dc.contributor.authorHazbun, Alexis
dc.contributor.authorHijazi, Assia
dc.contributor.authorVreede, Barbara
dc.contributor.authorRoch, Fernando
dc.contributor.authorSucena, Élio
dc.date.accessioned2017-09-14T15:25:29Z
dc.date.available2017-09-14T15:25:29Z
dc.date.issued2015-03-04
dc.descriptionThe deposited article version is a "MBE Advance Access" published on March 4, 2015" provided by Oxford University Press, and it contains attached the supplementary materials within the pdf.pt_PT
dc.descriptionThe deposited article is a post-print version.pt_PT
dc.descriptionSome supplementary materials are not present in the uploaded version of the article.pt_PT
dc.description.abstractGene families often consist of members with diverse expression domains reflecting their functions in a wide variety of tissues. However, how the expression of individual members, and thus their tissue-specific functions, diversified during the course of gene family expansion is not well understood. In this study, we approached this question through the analysis of the duplication history and transcriptional evolution of a rapidly expanding subfamily of insect Ly6 genes. We analyzed different insect genomes and identified seven Ly6 genes that have originated from a single ancestor through sequential duplication within the higher Diptera. We then determined how the original embryonic expression pattern of the founding gene diversified by characterizing its tissue-specific expression in the beetle Tribolium castaneum, the butterfly Bicyclus anynana, and the mosquito Anopheles stephensi and those of its duplicates in three higher dipteran species, representing various stages of the duplication history (Megaselia abdita, Ceratitis capitata, and Drosophila melanogaster). Our results revealed that frequent neofunctionalization episodes contributed to the increased expression breadth of this subfamily and that these events occurred after duplication and speciation events at comparable frequencies. In addition, at each duplication node, we consistently found asymmetric expression divergence. One paralog inherited most of the tissue-specificities of the founder gene, whereas the other paralog evolved drastically reduced expression domains. Our approach attests to the power of combining a well-established duplication history with a comprehensive coverage of representative species in acquiring unequivocal information about the dynamics of gene expression evolution in gene families.pt_PT
dc.description.sponsorshipIAEA Seibersdorf (Austria); USDA; Duke University; McGill University; DRGC (Kyoto); DSHB (Iowa); Toulouse RIO Imaging Platform; Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/75139/2010, ANR-13-ISV7-0001-01, ANR-13-ISV7-0001-02, FCT-ANR/BIA-ANM/0003/2013); Fundação Calouste Gulbenkian; Instituto Gulbenkian de Ciência; Agence Nationale de la Recherche (ANR).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKohtaro Tanaka, Yoan Diekmann, Alexis Hazbun, Assia Hijazi, Barbara Vreede, Fernando Roch, Élio Sucena; Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family, Molecular Biology and Evolution, Volume 32, Issue 7, 1 July 2015, Pages 1730–1747, https://doi.org/10.1093/molbev/msv052pt_PT
dc.identifier.doi10.1093/molbev/msv052pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/786
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationANR-13-ISV7-0001-01pt_PT
dc.relationANR-13-ISV7-0001-02pt_PT
dc.relation.publisherversionhttps://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/msv052pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectEmbryo, Nonmammalianpt_PT
dc.subjectEvolution, Molecularpt_PT
dc.subjectGene Duplicationpt_PT
dc.subjectGene Expression Profilingpt_PT
dc.subjectInsectspt_PT
dc.subjectOrgan Specificitypt_PT
dc.subjectPhylogenypt_PT
dc.subjectSpecies Specificitypt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectGenes, Insectpt_PT
dc.subjectMultigene Familypt_PT
dc.titleMultispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Familypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F75139%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/FCT-ANR%2FBIA-ANM%2F0003%2F2013/PT
oaire.citation.endPage1747pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1730pt_PT
oaire.citation.titleMolecular Biology and Evolutionpt_PT
oaire.citation.volume32pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication5a35965c-cc7d-4d59-847f-d805908f4aac
relation.isProjectOfPublicationdc1b3096-3901-45b4-98a4-27febbfefb91
relation.isProjectOfPublication.latestForDiscovery5a35965c-cc7d-4d59-847f-d805908f4aac

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