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Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection

dc.contributor.authorMarques, Filipe
dc.contributor.authorVale-Costa, Sílvia
dc.contributor.authorCruz, Tânia
dc.contributor.authorMarques, Joana Moreira
dc.contributor.authorSilva, Tânia
dc.contributor.authorNeves, João Vilares
dc.contributor.authorCortes, Sofia
dc.contributor.authorFernandes, Ana
dc.contributor.authorRocha, Eduardo
dc.contributor.authorAppelberg, Rui
dc.contributor.authorRodrigues, Pedro
dc.contributor.authorTomás, Ana M.
dc.contributor.authorGomes, Maria Salomé
dc.date.accessioned2015-12-21T17:16:05Z
dc.date.available2015-12-21T17:16:05Z
dc.date.issued2015-12
dc.description.abstractVisceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and severe visceral disease. Visceral leishmaniasis is more frequent in immunocompromised individuals and data obtained in experimental models of infection have highlighted the importance of the host immune response, namely the efficient activation of host's macrophages, in determining infection outcome. Conversely, few studies have addressed a possible contribution of parasite variability to this outcome.pt_PT
dc.description.sponsorshipNo funders or funding refered in the paper.pt_PT
dc.identifier.doi10.1186/s13071-015-1259-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/537
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttp://www.parasitesandvectors.com/content/8/1/644#refspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLeishmania infantumpt_PT
dc.titleStudies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleParasites & Vectorspt_PT
oaire.citation.volume8pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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