Publication
Modelling the onset of senescence at the G1/S cell cycle checkpoint
| dc.contributor.author | Mombach, José CM | |
| dc.contributor.author | Bugs, Cristhian A | |
| dc.contributor.author | Chaouiya, Claudine | |
| dc.date.accessioned | 2015-10-01T16:44:50Z | |
| dc.date.available | 2015-10-01T16:44:50Z | |
| dc.date.issued | 2014-10-27 | |
| dc.description.abstract | DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a growing scientific interest. Here, we advance a qualitative model covering DNA damage response pathways, focusing on G1/S checkpoint enforcement, supposedly more sensitive to arrest than G2/M checkpoint. | pt_PT |
| dc.description.sponsorship | Instituto Gulbenkian de Ciência (IGC), the Brazilian agency CNPq for financial support (grants 236673/2012-2, 304805/2012-2, 402547/2012-8). | pt_PT |
| dc.identifier | 10.1186/1471-2164-15-S7-S7 | |
| dc.identifier.doi | 10.1186/1471-2164-15-S7-S7 | |
| dc.identifier.doi | 10.1186/1471-2164-15-S7-S7 | |
| dc.identifier.uri | http://hdl.handle.net/10400.7/339 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | BioMed Central | pt_PT |
| dc.relation.publisherversion | http://www.biomedcentral.com/1471-2164/15/S7/S7 | pt_PT |
| dc.subject | Signalling network | pt_PT |
| dc.subject | Logical modelling | pt_PT |
| dc.subject | Senescence | pt_PT |
| dc.subject | DNA-damage | pt_PT |
| dc.subject | Cell fate | pt_PT |
| dc.subject | Cell cycle checkpoint | pt_PT |
| dc.title | Modelling the onset of senescence at the G1/S cell cycle checkpoint | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 11 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | BMC Genomics | pt_PT |
| oaire.citation.volume | 15 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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