Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria

Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.

Palavras-chave

Plasmodium falciparum Severe malaria Cerebral malaria Acute-renal failure Malaria associated organ failure IL-17 Cytokines Biomarkers

URI

http://hdl.handle.net/10400.7/528

Editora

BioMed Central

DOI

10.1186/s12967-015-0731-6

Coleções

LAIR articles

Licença CC

cclicense-by

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