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Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria

2015-11-24Journal article Open access
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dc.contributor.authorHerbert, Fabien
dc.contributor.authorTchitchek, Nicolas
dc.contributor.authorBansal, Devendra
dc.contributor.authorJacques, Julien
dc.contributor.authorPathak, Sulabha
dc.contributor.authorBécavin, Christophe
dc.contributor.authorFesel, Constantin
dc.contributor.authorDalko, Esther
dc.contributor.authorCazenave, Pierre-André
dc.contributor.authorPreda, Cristian
dc.contributor.authorRavindran, Balachandran
dc.contributor.authorSharma, Shobhona
dc.contributor.authorDas, Bidyut
dc.contributor.authorPied, Sylviane
dc.date.accessioned2015-11-30T11:55:25Z
dc.date.available2015-11-30T11:55:25Z
dc.date.issued2015-11-24
dc.description.abstractPlasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.pt_PT
dc.description.sponsorshipIndo-French Centre for the Promotion of Advanced Research (IFCPAR project No 3703), International Associated Laboratory Systems Immunology and Genetics of Infectious Diseases (LIA SIGID, CNRS, Lille University and the Department of Biotechnology (DBT), Ministry of Science and Technology of India and the ANR LAbEx Parafrap).pt_PT
dc.identifier.doi10.1186/s12967-015-0731-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/528
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relationIndo-French Centre for the Promotion of Advanced Research (IFCPAR project No 3703)pt_PT
dc.relation.publisherversionhttp://www.translational-medicine.com/content/13/1/369pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPlasmodium falciparumpt_PT
dc.subjectSevere malariapt_PT
dc.subjectCerebral malariapt_PT
dc.subjectAcute-renal failurept_PT
dc.subjectMalaria associated organ failurept_PT
dc.subjectIL-17pt_PT
dc.subjectCytokinespt_PT
dc.subjectBiomarkerspt_PT
dc.titleEvidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malariapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage11pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Translational Medicinept_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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