Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human Plasmodium infection

Fesel, C.; Goulart, L.F.; Neto, A.S.; Coelho, A.; Fontes, C.J.F.; Braga, E.M.; Vaz, N.M.

http://hdl.handle.net/10400.7/216

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Abstract(s)

The observed difference in polyclonal antibody production seems related to intrinsic activation states of infected individuals, rather than to parasite-antigen specific immune responses. However, it appears influenced by preceding stimuli. This supports the idea that acquired clinical immunity may not exclusively depend on antigen-specific responses, but also on the individual polyclonal reaction.

Keywords

Immunity, Innate/immunology Immunoglobulin G/blood Immunoglobulin G/immunology Malaria, Falciparum/epidemiology Malaria, Falciparum/immunology Malaria, Vivax/epidemiology Malaria, Vivax/immunology Escherichia coli Proteins/immunology

URI

http://hdl.handle.net/10400.7/216
http://dx.doi.org/10.1186/1475-2875-4-5

Citation

Fesel, C., L. F. Goulart, A. S. Neto, A. Coelho, C. J. F. Fontes, E. M. Braga and N. M. Vaz (2005). "Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human Plasmodium infection." Malaria Journal 4:5