iRhom2 and TNF: Partners or enemies?

Badenes, Marina; Adrain, Colin

http://hdl.handle.net/10400.7/956

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Authors

Badenes, Marina

Adrain, Colin

Abstract(s)

iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor-α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.