Publication
iRhom2 and TNF: Partners or enemies?
| dc.contributor.author | Badenes, Marina | |
| dc.contributor.author | Adrain, Colin | |
| dc.date.accessioned | 2020-05-01T10:58:08Z | |
| dc.date.available | 2020-05-01T10:58:08Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor-α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1126/scisignal.aaz0444 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.7/956 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | Project LISBOA-01-0145- FEDER-031330 - FCT | pt_PT |
| dc.relation | La Caixa” Foundation (ID 100010434) - LCF/PR/HR17/52150018 | pt_PT |
| dc.subject | iRhom2; ADAM17 | pt_PT |
| dc.subject | TNF | pt_PT |
| dc.title | iRhom2 and TNF: Partners or enemies? | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 605 | pt_PT |
| oaire.citation.startPage | eaaz0444 | pt_PT |
| oaire.citation.title | Science Signaling | pt_PT |
| oaire.citation.volume | 12 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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