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Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution

2014-02Journal article Open access
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dc.contributor.authorJana, Swadhin Chandra
dc.contributor.authorMarteil, Gaëlle
dc.contributor.authorBettencourt-Dias, Mónica
dc.date.accessioned2018-02-06T17:12:39Z
dc.date.available2018-02-06T17:12:39Z
dc.date.issued2014-02
dc.descriptionThe deposited article is a post-print version and has been subjected to peer review.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThere is no public supplementary material available.pt_PT
dc.description.abstractCentrioles are microtubule (MT)-based cylinders that form centrosomes and can be modified into basal bodies that template the axoneme, the ciliary MT skeleton. These MT-based structures are present in all branches of the eukaryotic tree of life, where they have important sensing, motility and cellular architecture-organizing functions. Moreover, they are altered in several human conditions and diseases, including sterility, ciliopathies and cancer. Although the ultrastructure of centrioles and derived organelles has been known for over 50 years, the molecular basis of their remarkably conserved properties, such as their 9-fold symmetry, has only now started to be unveiled. Recent advances in imaging, proteomics and crystallography, allowed the building of 3D models of centrioles and derived structures with unprecedented molecular details, leading to a much better understanding of their assembly and function. Here, we cover progress in this field, focusing on the mechanisms of centriole and cilia assembly.pt_PT
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT) grants: (HMSP-CT/SAU-ICT/0075/2009,PTDC/BIA-BCM/105602/2008, PTDC/BIA-BCM/112736/2009, PTDC/SAU-OBD/105616/2008); BPD Fellowship; Harvard Medical School; EMBO installation grant; ERC starting grant.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ceb.2013.12.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/828
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMicrotubule Regulation in Centriole Biogenesis Mechanisms
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0955067413001889?via%3Dihubpt_PT
dc.subjectAnimalspt_PT
dc.subjectCentriolespt_PT
dc.subjectCiliapt_PT
dc.subjectHumanspt_PT
dc.subjectMicroscopy, Atomic Forcept_PT
dc.subjectMicrotubulespt_PT
dc.subjectNanostructurespt_PT
dc.subjectOrganellespt_PT
dc.titleMapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolutionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicrotubule Regulation in Centriole Biogenesis Mechanisms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-CT%2FSAU-ICT%2F0075%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F105602%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F112736%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F105616%2F2008/PT
oaire.citation.endPage106pt_PT
oaire.citation.startPage96pt_PT
oaire.citation.titleCurrent Opinion in Cell Biologypt_PT
oaire.citation.volume26pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublicationfb2b2147-605d-4317-85e3-894cad34c70c
relation.isProjectOfPublication5ee017da-34f9-4b2d-aeb4-156c43e94484
relation.isProjectOfPublication1848efe2-6ac0-4b9c-a402-c3138611e8d1
relation.isProjectOfPublication.latestForDiscovery950d9933-b1f8-43c9-834b-36eda23788ff

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