The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1viaNuclear Factor Erythroid-2-Related Factor 2

Parada, Esther; Egea, Javier; Buendia, Izaskun; Negredo, Pilar; Cunha, Ana C.; Cardoso, Silvia; Soares, Miguel P.; López, Manuela G.

http://hdl.handle.net/10400.7/772

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Abstract(s)

We asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or the expression of its target cytoprotective gene, heme oxygenase-1 (HO-1). Specifically, the protective effect of the pharmacologic alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonist PNU282987 was analyzed in organotypic hippocampal cultures (OHCs) subjected to oxygen and glucose deprivation (OGD) in vitro as well as in photothrombotic stroke in vivo.

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Keywords

Animals Anti-Inflammatory Agents Antioxidants Cell Death Cell Survival Cerebral Infarction Cultural Deprivation Heme Oxygenase-1 Hippocampus Mice Mice, Transgenic Microglia NF-E2-Related Factor 2 Neuroprotective Agents Nicotinic Agonists Organ Culture Techniques Oxidative Stress Rats Reactive Oxygen Species Signal Transduction Tumor Necrosis Factor-alpha alpha7 Nicotinic Acetylcholine Receptor

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http://hdl.handle.net/10400.7/772

Citation

Esther Parada, Javier Egea, Izaskun Buendia, Pilar Negredo, Ana C. Cunha, Silvia Cardoso, Miguel P. Soares, and Manuela G. López. Antioxidants & Redox Signaling. September 2013, 19(11): 1135-1148. https://doi.org/10.1089/ars.2012.4671