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The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1viaNuclear Factor Erythroid-2-Related Factor 2

2013-09-26Journal article Open access
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dc.contributor.authorParada, Esther
dc.contributor.authorEgea, Javier
dc.contributor.authorBuendia, Izaskun
dc.contributor.authorNegredo, Pilar
dc.contributor.authorCunha, Ana C.
dc.contributor.authorCardoso, Silvia
dc.contributor.authorSoares, Miguel P.
dc.contributor.authorLópez, Manuela G.
dc.date.accessioned2017-06-22T19:20:26Z
dc.date.available2017-06-22T19:20:26Z
dc.date.issued2013-09-26
dc.descriptionThe deposited article is a post-print version.pt_PT
dc.descriptionThis deposit is composed by the main article, and it hasn't any supplementary materials associated.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.description.abstractWe asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or the expression of its target cytoprotective gene, heme oxygenase-1 (HO-1). Specifically, the protective effect of the pharmacologic alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonist PNU282987 was analyzed in organotypic hippocampal cultures (OHCs) subjected to oxygen and glucose deprivation (OGD) in vitro as well as in photothrombotic stroke in vivo.pt_PT
dc.description.sponsorshipSpanish Ministry of Science and Innovation grant: (SAF2009-12150, SAF2012-3222); Spanish Ministry of Health grant: (RETICS-RD06/0026); Spanish Ministry of Economy predoctoral fellowship; Fundación Teófilo Hernando; Fundação para a Ciência e Tecnologia grants: (PTDC/BIA-BCM/101311/2008, PTDC/SAU-FCF/100762/2008, PTDC/SAU-TOX/116627/2010); European Research Council grant: (ERC-2011-AdG. 294709–DAMAGECONTROL); Instituto Gulbenkian de Ciência.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEsther Parada, Javier Egea, Izaskun Buendia, Pilar Negredo, Ana C. Cunha, Silvia Cardoso, Miguel P. Soares, and Manuela G. López. Antioxidants & Redox Signaling. September 2013, 19(11): 1135-1148. https://doi.org/10.1089/ars.2012.4671pt_PT
dc.identifier.doi10.1089/ars.2012.4671pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/772
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebertpt_PT
dc.relationSAF2009-12150pt_PT
dc.relationSAF2012-3222pt_PT
dc.relationRETICS-RD06/0026pt_PT
dc.relationModulation of programmed cell death by cellular free heme
dc.relationLSH-2005-1.2.5-1pt_PT
dc.relationTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
dc.relation.publisherversionhttp://online.liebertpub.com/doi/abs/10.1089/ars.2012.4671pt_PT
dc.subjectAnimalspt_PT
dc.subjectAnti-Inflammatory Agentspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectCell Deathpt_PT
dc.subjectCell Survivalpt_PT
dc.subjectCerebral Infarctionpt_PT
dc.subjectCultural Deprivationpt_PT
dc.subjectHeme Oxygenase-1pt_PT
dc.subjectHippocampuspt_PT
dc.subjectMicept_PT
dc.subjectMice, Transgenicpt_PT
dc.subjectMicrogliapt_PT
dc.subjectNF-E2-Related Factor 2pt_PT
dc.subjectNeuroprotective Agentspt_PT
dc.subjectNicotinic Agonistspt_PT
dc.subjectOrgan Culture Techniquespt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectRatspt_PT
dc.subjectReactive Oxygen Speciespt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectTumor Necrosis Factor-alphapt_PT
dc.subjectalpha7 Nicotinic Acetylcholine Receptorpt_PT
dc.titleThe Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1viaNuclear Factor Erythroid-2-Related Factor 2pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleModulation of programmed cell death by cellular free heme
oaire.awardTitleTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F101311%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FCF%2F100762%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-TOX%2F116627%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294709/EU
oaire.citation.endPage1148pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1135pt_PT
oaire.citation.titleAntioxidants and Redox Signalingpt_PT
oaire.citation.volume19pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication07a35b73-a323-4c2c-b7af-d0d76fd04235
relation.isProjectOfPublication18eed6ef-a13c-41ee-a71e-f2899a49711b
relation.isProjectOfPublication72d8fa6f-1215-4a61-bc70-515eef334d45
relation.isProjectOfPublication370f9aad-c4ef-4e35-b754-edc840dc6b5e
relation.isProjectOfPublication.latestForDiscovery370f9aad-c4ef-4e35-b754-edc840dc6b5e

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