Sepsis: the need for tolerance not complacency

Velho, Tiago R; Santos, Isa; Póvoa, Pedro; Moita, Luis Ferreira

Publication

Sepsis: the need for tolerance not complacency

2016-02-22Journal article

dc.contributor.author	Velho, Tiago R
dc.contributor.author	Santos, Isa
dc.contributor.author	Póvoa, Pedro
dc.contributor.author	Moita, Luis Ferreira
dc.date.accessioned	2016-02-29T13:21:10Z
dc.date.available	2016-02-29T13:21:10Z
dc.date.issued	2016-02-22
dc.description.abstract	Sepsis is a life-threatening condition that arises as a systemic inflammatory response syndrome to an infection. Its uncontrolled progression can in frequent cases lead to multiple organ failure, which is still associated with high mortality rates. Modern antibiotics made clear that the infection is only an initiating, and not always necessary, event of this syndrome as many patients with sepsis die despite effective eradication of the inciting pathogen. This observation critically contributed to a paradigm shift that focused the pathogenesis of sepsis on the host and not on the pathogen. However, therapeutic strategies based on the inhibition of proinflammatory critical mediators of sepsis or immunostimulation have so far failed to improve sepsis outcome and, therefore, this condition urgently needs transformative therapeutic ideas and strategies. Here we argue that the induction of tolerance, a defence strategy that minimises the impact of an infection on organ function without directly affecting the pathogen burden, is perhaps the missing but essential element to add to the current components of sepsis care and treatment.	pt_PT
dc.description.sponsorship	IGC Integrative Biology and Biomedicine (IBB) PhD Program, FCT, European Research Council (ERC-2014-CoG 647888-iPROTECTION).	pt_PT
dc.identifier.citation	Swiss Med Wkly. 2016;146:w14276	pt_PT
dc.identifier.doi	10.4414/smw.2016.14276	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/552
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	EMH SWISS MEDICAL PUBLISHERS	pt_PT
dc.relation.publisherversion	http://www.smw.ch/content/smw-2016-14276/	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	sepsis	pt_PT
dc.subject	tolerance	pt_PT
dc.title	Sepsis: the need for tolerance not complacency	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	4	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	Swiss Medical Weekly	pt_PT
oaire.citation.volume	146	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT