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Glutamate receptor-like channels are essential for chemotaxis and reproduction in mosses

2017-07-24Journal article Open access
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dc.contributor.authorOrtiz-Ramírez, Carlos
dc.contributor.authorMichard, Erwan
dc.contributor.authorSimon, Alexander A.
dc.contributor.authorDamineli, Daniel S. C.
dc.contributor.authorHernández-Coronado, Marcela
dc.contributor.authorBecker, Jörg D.
dc.contributor.authorFeijó, José A.
dc.date.accessioned2017-08-03T14:41:29Z
dc.date.available2018-07-01T00:30:08Z
dc.date.issued2017-07-24
dc.descriptionThe deposited article version is a "Accelerated Article Preview" provided by Nature Publishing Group, and it contains attached the supplementary materials within the pdf.». This publication hasn't any creative commons license associated.pt_PT
dc.description.abstractGlutamate receptors are well characterized channels that mediate cell-to-cell communication during neurotransmission in animals. Nevertheless, information regarding their functional role in organisms without nervous systems is still limited. In plants, Glutamate Receptor-like (GLR) genes have been implicated in defence against pathogens, reproduction, control of stomata aperture and light signal transduction(1-5). However, the numerous GLR genes present in angiosperm genomes (20 to 70)(6) has prevented the observation of strong phenotypes in loss-of-function mutants. Here, we show that in the moss Physcomitrella patens, a basal land plant, mutation of GLR genes cause sperm failure in targeting the female reproductive organs. In addition, we show that GLR genes encode non-selective Ca(2+) permeable channels that can regulate cytoplasmic Ca(2+) and are needed to induce the expression of a BELL1-like transcription factor essential for zygote development. Our work reveals novel functions for GLRs in sperm chemotaxis and transcriptional regulation. Sperm chemotaxis is essential for fertilization in both animals and early land plants like bryophytes and pteridophytes. Therefore, our results are suggestive that ionotropic glutamate receptors may have been conserved throughout plant evolution to mediate cell-to-cell communication during sexual reproduction.pt_PT
dc.description.sponsorshipPhillips University; Oxford University; University of Marburg; University of Muenster; MarieCurie ITN-Plant Origins grant: (FP7-PEOPLE-ITN-2008); FCT grants: (BEX-BCM/0376/2012; PTDC/BIA-PLA/4018/2012); NSF-US grant: (MCB 1616437/2016).pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationOrtiz-Ramírez, C. et al. Glutamate receptor-like channels are essential for chemotaxis and reproduction in mosses. Nature http://dx.doi.org/10.1038/nature23478 (2017)pt_PT
dc.identifier.doi10.1038/nature23478pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/780
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationFP7-PEOPLE-ITN-2008pt_PT
dc.relationMCB1616437/2016pt_PT
dc.relation.publisherversionhttps://www.nature.com/nature/journal/vaap/ncurrent/full/nature23478.htmlpt_PT
dc.subjectFertilizationpt_PT
dc.subjectEvolutionary developmental biologypt_PT
dc.titleGlutamate receptor-like channels are essential for chemotaxis and reproduction in mossespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BCM%2F0376%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-PLA%2F4018%2F2012/PT
oaire.citation.endPage24pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNaturept_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctThe deposited article has 12 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo between 6 months after the date of the publication, and since the article hasn't been published it has a extended date of embargo, as a preventive measure.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationa6c8d6b9-6beb-4205-a0a5-7e57a0aaf99d
relation.isProjectOfPublication8869b2a9-f7d7-4481-9d6b-9c18f6408fb4
relation.isProjectOfPublication.latestForDiscoverya6c8d6b9-6beb-4205-a0a5-7e57a0aaf99d

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