Publication
How two become one: HJURP dimerization drives CENP-A assembly
| dc.contributor.author | Bodor, Dani L | |
| dc.contributor.author | Jansen, Lars E T | |
| dc.date.accessioned | 2016-05-24T12:22:08Z | |
| dc.date.available | 2016-05-24T12:22:08Z | |
| dc.date.issued | 2013-06-21 | |
| dc.description.abstract | CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nucleosomes. A recent publication in The EMBO Journal (Zasadzińska et al, 2013) demonstrates that HJURP itself dimerizes through a C‐terminal repeat region, which is essential for centromeric assembly of nascent CENP‐A. | pt_PT |
| dc.description.sponsorship | FCT fellowship: (SFRH/BD/74284/2010); FCT grants: (BIA-BCM/100557/2008, BIAPRO/100537/2008); EMBO Installation Grant. | pt_PT |
| dc.identifier.citation | Bodor, D. L., Jansen, L. E. T. (2013). How two become one: HJURP dimerization drives CENP-A assembly. EMBO J., 32(15), 2090–2092. | pt_PT |
| dc.identifier.doi | 10.1038/emboj.2013.150 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.7/618 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Embo Press | pt_PT |
| dc.relation.publisherversion | http://emboj.embopress.org/content/32/15/2090 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Autoantigens | pt_PT |
| dc.subject | Centromere | pt_PT |
| dc.subject | Chromosomal Proteins, Non-Histone | pt_PT |
| dc.subject | DNA-Binding Proteins | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Nucleosomes | pt_PT |
| dc.subject | Protein Multimerization | pt_PT |
| dc.title | How two become one: HJURP dimerization drives CENP-A assembly | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 2092 | pt_PT |
| oaire.citation.issue | 15 | pt_PT |
| oaire.citation.startPage | 2090 | pt_PT |
| oaire.citation.title | The EMBO Journal | pt_PT |
| oaire.citation.volume | 32 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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