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Diet leaves a genetic signature in a keystone member of the gut microbiota

dc.contributor.authorDapa, Tanja
dc.contributor.authorRamiro, Ricardo Serotte
dc.contributor.authorPedro, Miguel Filipe
dc.contributor.authorGordo, Isabel
dc.contributor.authorXavier, Karina Bivar
dc.date.accessioned2022-03-10T15:55:52Z
dc.date.available2022-03-10T15:55:52Z
dc.date.issued2022
dc.description.abstractSwitching from a low-fat and high-fiber diet to a Western-style high-fat and high-sugar diet causes microbiota imbalances that underlay many pathological conditions (i.e., dysbiosis). Although the effects of dietary changes on microbiota composition and functions are well documented, their impact in gut bacterial evolution remains unexplored. We followed the emergence of mutations in Bacteroides thetaiotaomicron, a prevalent fiber-degrading microbiota member, upon colonization of the murine gut under different dietary regimens. B. thetaiotaomicron evolved rapidly in the gut and Western-style diet selected for mutations that promote degradation of mucin-derived glycans. Periodic dietary changes caused fluctuations in the frequency of such mutations and were associated with metabolic shifts, resulting in the maintenance of higher intraspecies genetic diversity compared to constant dietary regimens. These results show that dietary changes leave a genetic signature in microbiome members and suggest that B. thetaiotaomicron genetic diversity could be a biomarker for dietary differences among individuals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chom.2022.01.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/976
dc.language.isoengpt_PT
dc.relationFCT, ONEIDA, CONGENTO and FEEI (Fundos Europeus Estruturais e de Investimento from Programa Operacional Regional Lisboa 2020.)pt_PT
dc.subjectmicrobiota, high-fat high-sugar diet, Western-style diet, microbiota evolution, gut dysbiosis, Bacteroides thetaiotaomicron, Bacteroidetes, gut metabolon, gut ecology, multi-omics analysespt_PT
dc.titleDiet leaves a genetic signature in a keystone member of the gut microbiotapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacehttps://www.sciencedirect.com/science/article/pii/S1931312822000385?dgcid=author
oaire.citation.endPage199.e10pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage183pt_PT
oaire.citation.titleCell Host & Microbept_PT
oaire.citation.volume30pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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