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Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model

2015-01-06Journal article Open access
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dc.contributor.authorSantos, António
dc.contributor.authorLopes, Teresa
dc.contributor.authorOleastro, Mónica
dc.contributor.authorGato, Inês
dc.contributor.authorFloch, Pauline
dc.contributor.authorBenejat, Lucie
dc.contributor.authorChaves, Paula
dc.contributor.authorPereira, Teresa
dc.contributor.authorSeixas, Elsa
dc.contributor.authorMachado, Jorge
dc.contributor.authorGuerreiro, António
dc.date.accessioned2017-02-15T18:45:37Z
dc.date.available2017-02-15T18:45:37Z
dc.date.issued2015-01-06
dc.description.abstractHelicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to find alternative therapies, particularly in the nutritional field. The current study evaluated whether curcumin could attenuate inflammation of the gastric mucosa due to H. pylori infection. Twenty-eight C57BL/6 mice, were inoculated with the H. pylori SS1 strain; ten non-infected mice were used as controls. H. pylori infection in live mice was followed-up using a modified 13C-Urea Breath Test (13C-UBT) and quantitative real-time polymerase chain reaction (PCR). Histologically confirmed, gastritis was observed in 42% of infected non-treated mice at both 6 and 18 weeks post-infection. These mice showed an up-regulation of the expression of inflammatory cytokines and chemokines, as well as of toll-like receptors (TLRs) and MyD88, at both time points. Treatment with curcumin decreased the expression of all these mediators. No inflammation was observed by histology in this group. Curcumin treatment exerted a significant anti-inflammatory effect in H. pylori-infected mucosa, pointing to the promising role of a nutritional approach in the prevention of H. pylori induced deleterious inflammation while the eradication or prevention of colonization by effective vaccine is not available.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos, A.M.; Lopes, T.; Oleastro, M.; Gato, I.V.; Floch, P.; Benejat, L.; Chaves, P.; Pereira, T.; Seixas, E.; Machado, J.; Guerreiro, A.S. Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model. Nutrients 2015, 7, 306-320.pt_PT
dc.identifier.doi10.3390/nu7010306pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/733
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2072-6643/7/1/306pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectH. pyloript_PT
dc.subjectcurcuminpt_PT
dc.subjectnutritional approachpt_PT
dc.subjectsecondary preventionpt_PT
dc.subjectmouse modelpt_PT
dc.titleCurcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Modelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OSM%2F66323%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F34094%2F2006/PT
oaire.citation.endPage320pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage306pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationfd8e8c88-7616-480b-9628-082421aa3ab8
relation.isProjectOfPublication20414027-876a-412d-9400-a09970ab833b
relation.isProjectOfPublication.latestForDiscovery20414027-876a-412d-9400-a09970ab833b

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