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Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisians

2014-01-01Journal article Restricted access
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dc.contributor.authorZouidi, Ferjeni
dc.contributor.authorStayoussef, Mouna
dc.contributor.authorBouzid, Dorra
dc.contributor.authorFourati, Hajer
dc.contributor.authorAbida, Olfa
dc.contributor.authorAyed, M. Ben
dc.contributor.authorKammoun, Thouraya
dc.contributor.authorHachicha, Monjia
dc.contributor.authorPenha-Gonçalves, Carlos
dc.contributor.authorMasmoudi, Hatem
dc.date.accessioned2018-05-25T15:51:26Z
dc.date.available2018-05-25T15:51:26Z
dc.date.issued2014-01-01
dc.descriptionThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0378111913013462?via%3Dihub#s0060pt_PT
dc.descriptionThis deposit is composed by the main article, and it hasn't any supplementary materials associated.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.description.abstractType 1 diabetes (T1D) is caused by an immune-mediated destruction of the insulin-producing β-cells. Several studies support the involvement of T cell activation molecules. In order to underline the role of the genes involved in this pathway, we investigated, using the Sequenom MassARRAY platform, polymorphisms of sixteen single-nucleotide polymorphisms (SNPs) belonging to PTPN22, CD28, CTLA-4, and ZAP-70 genes in 76 T1D patients and 162 unrelated healthy controls from Southern Tunisia. We confirmed the association with PTPN22 (rs2476601, Corrected P (Pcorr)=0.002, OR=6.20) and CD28 gene (rs1879877, Pcorr=0.003; OR=4.27 and rs3181096, Pcorr=0.02; OR=1.73). We also identified an association with rs17695937 of ZAP-70 gene (Pcorr=0.02, OR=1.87). Our results suggest a significant effect on T1D susceptibility for A-C-A-G-C and T-C-C-T-A-C haplotypes, of ZAP-70 and CD28 genes, respectively. In addition, (A-G-C) combination of ZAP-70/CD28 gene was significantly increased in T1D patients as compared to controls, suggesting the possible interaction between these genes. These results confirm the involvement of PTPN22 and CD28 genes in the genetic susceptibility to T1D. Interestingly, ZAP-70 seems to contribute to the susceptibility to the disease in our population. However, this finding has to be confirmed in further studies.pt_PT
dc.description.sponsorshipThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZouidi, F., Stayoussef, M., Bouzid, D., Fourati, H., Abida, O., Ayed, M.B., Kammoun, T., Hachicha, M., Penha-Gonçalves, C., Masmoudi, H. (2014) Contribution Of Ptpn22, Cd28, Ctla-4 And Zap-70 Variants To The Risk Of Type 1 Diabetes In Tunisians. Gene. 533(1): 420-426.pt_PT
dc.identifier.doi10.1016/j.gene.2013.09.112pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/886
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378111913013462?via%3Dihubpt_PT
dc.subjecttype 1 diabetespt_PT
dc.subjectZAP-70pt_PT
dc.subjectCD28pt_PT
dc.subjectPTPN22pt_PT
dc.subjectCTLA-4 genespt_PT
dc.subjectTunisiapt_PT
dc.titleContribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisianspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage426pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage420pt_PT
oaire.citation.titleGenept_PT
oaire.citation.volume533pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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