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Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity

2016-07-21Journal article Open access
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dc.contributor.authorAires, Rita
dc.contributor.authorJurberg, Arnon D.
dc.contributor.authorLeal, Francisca
dc.contributor.authorNóvoa, Ana
dc.contributor.authorCohn, Martin J.
dc.contributor.authorMallo, Moisés
dc.date.accessioned2017-05-17T11:28:30Z
dc.date.available2017-07-30T00:30:08Z
dc.date.issued2016-07-21
dc.descriptionThe deposited article version is a post-print version (final draft post-refereeing) and included supplementary information.pt_PT
dc.description.abstractVertebrates exhibit a remarkably broad variation in trunk and tail lengths. However, the evolutionary and developmental origins of this diversity remain largely unknown. Posterior Hox genes were proposed to be major players in trunk length diversification in vertebrates, but functional studies have so far failed to support this view. Here we identify the pluripotency factor Oct4 as a key regulator of trunk length in vertebrate embryos. Maintaining high Oct4 levels in axial progenitors throughout development was sufficient to extend trunk length in mouse embryos. Oct4 also shifted posterior Hox gene-expression boundaries in the extended trunks, thus providing a link between activation of these genes and the transition to tail development. Furthermore, we show that the exceptionally long trunks of snakes are likely to result from heterochronic changes in Oct4 activity during body axis extension, which may have derived from differential genomic rearrangements at the Oct4 locus during vertebrate evolution.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: ( PTDC/BEX-BID/0899/2014, SFRH/BD/51876/2012); Santa Casa da Misericordia de Lisboa grant: (SCML-MC-60-2014); Howard Hughes Medical; HHMI international graduate student research fellowship.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRita Aires, Arnon D. Jurberg, Francisca Leal, Ana Nóvoa, Martin J. Cohn, Moisés Mallo, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity, Developmental Cell, Volume 38, Issue 3, 8 August 2016, Pages 262-274, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2016.06.021. (http://www.sciencedirect.com/science/article/pii/S1534580716304245)pt_PT
dc.identifier.doi10.1016/j.devcel.2016.06.021pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/755
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSCML-MC-60-2014pt_PT
dc.relationLONG TERM AXIAL PROGENITORS: CHARACTERIZATION AND CELLULAR DYNAMICS DURING MOUSE EMBRYONIC AXIAL ELONGATION
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1534580716304245pt_PT
dc.subjectOct4pt_PT
dc.subjectHox genespt_PT
dc.subjectvertebratespt_PT
dc.subjectgene-expressionpt_PT
dc.subjectgenomicpt_PT
dc.titleOct4 Is a Key Regulator of Vertebrate Trunk Length Diversitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLONG TERM AXIAL PROGENITORS: CHARACTERIZATION AND CELLULAR DYNAMICS DURING MOUSE EMBRYONIC AXIAL ELONGATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F0899%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F51876%2F2012/PT
oaire.citation.endPage274pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage262pt_PT
oaire.citation.titleDevelopmental Cellpt_PT
oaire.citation.volume38pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1aa95bd5-02a2-43c2-bd5f-8bd78d049780
relation.isProjectOfPublication994b5563-16a3-442c-9ed1-950b0ea4471d
relation.isProjectOfPublication.latestForDiscovery994b5563-16a3-442c-9ed1-950b0ea4471d

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