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Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7
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Orientador(es)
Resumo(s)
Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now
report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively
during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool
of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1
and marginal zone (MZ) compartments. This is accompanied by a 50-fold increase in the frequency
of immunoglobulin (Ig)M- and IgG-secreting cells, and the concentration of serum
immunoglobulins is increased three- to fivefold. Both the MZ phenotype and the increase in
serum IgM are T cell independent. These findings reveal a previously undescribed pathway of
B lymphopoiesis that is active in early life and is interleukin 7 independent. This pathway generates
B1 cells and a normal sized MZ B lymphocyte compartment.
Descrição
This deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link:
https://f1000.com/prime/1003667
Palavras-chave
B lymphocyte interleukin 7 marginal zone B cells B1 cells B cell development
Contexto Educativo
Citação
Carvalho, T.L., Mota-Santos T., Cumano A., Demergeot J., Vieira P. (2001) " Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7". Journal of Experimental Medicine. 194 (8):1141-1150 OCT