Publication
Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7
| dc.contributor.author | Carvalho, Thiago L. | |
| dc.contributor.author | Mota-Santos, Tomaz | |
| dc.contributor.author | Cumano, Ana | |
| dc.contributor.author | Demengeot, Jocelyne | |
| dc.contributor.author | Paulo, Vieira | |
| dc.date.accessioned | 2010-07-20T15:43:42Z | |
| dc.date.available | 2010-07-20T15:43:42Z | |
| dc.date.issued | 2001-10-15 | |
| dc.description | This deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: https://f1000.com/prime/1003667 | pt |
| dc.description.abstract | Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal zone (MZ) compartments. This is accompanied by a 50-fold increase in the frequency of immunoglobulin (Ig)M- and IgG-secreting cells, and the concentration of serum immunoglobulins is increased three- to fivefold. Both the MZ phenotype and the increase in serum IgM are T cell independent. These findings reveal a previously undescribed pathway of B lymphopoiesis that is active in early life and is interleukin 7 independent. This pathway generates B1 cells and a normal sized MZ B lymphocyte compartment. | pt |
| dc.identifier.citation | Carvalho, T.L., Mota-Santos T., Cumano A., Demergeot J., Vieira P. (2001) " Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7". Journal of Experimental Medicine. 194 (8):1141-1150 OCT | pt |
| dc.identifier.issn | 0022-1007 | |
| dc.identifier.uri | http://hdl.handle.net/10400.7/132 | |
| dc.language.iso | eng | pt |
| dc.relation.publisherversion | http://jem.rupress.org/content/194/8/1141.long | pt |
| dc.subject | B lymphocyte | pt |
| dc.subject | interleukin 7 | pt |
| dc.subject | marginal zone B cells | pt |
| dc.subject | B1 cells | pt |
| dc.subject | B cell development | pt |
| dc.title | Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7 | pt |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1150 | pt |
| oaire.citation.startPage | 1141 | pt |
| oaire.citation.title | Journal of Experimental Medicine | pt |
| rcaap.rights | restrictedAccess | pt |
| rcaap.type | article | pt |