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Evolutionary cell biology: two origins, one objective

2014-12-02Journal article Open access
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dc.contributor.authorLynch, Michael
dc.contributor.authorField, Mark C
dc.contributor.authorGoodson, Holly V
dc.contributor.authorMalik, Harmit S
dc.contributor.authorPereira-Leal, José B
dc.contributor.authorRoos, David S
dc.contributor.authorTurkewitz, Aaron P
dc.contributor.authorSazer, Shelley
dc.date.accessioned2015-10-05T13:31:13Z
dc.date.available2015-10-05T13:31:13Z
dc.date.issued2014-12-02
dc.description.abstractAll aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.pt_PT
dc.description.sponsorshipNational Science Foundation-sponsored Workshop on Evolutionary Cell Biology (Grant MCB-1228570), National Science Foundation Grants: ( IOS-1051962, MCB-1050161, MCB-1051985 and MCB-1244593), National Institutes of Health Grants: ( R01-GM036827, R01-105783, R01-GM74108, R01-AI49301), US Army Research Office Grant: (W911NF-09-1-0444), Howard Hughes Medical Institute.pt_PT
dc.identifier10.1073/pnas.1415861111
dc.identifier.citationMichael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Roos, Aaron P. Turkewitz, and Shelley Sazer Evolutionary cell biology: Two origins, one objective PNAS 2014 111 (48) 16990-16994; published ahead of print November 17, 2014, doi:10.1073/pnas.1415861111pt_PT
dc.identifier.doi10.1073/pnas.1415861111
dc.identifier.doi10.1073/pnas.1415861111
dc.identifier.urihttp://hdl.handle.net/10400.7/350
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencespt_PT
dc.relationPerda de robustez como um princípio de reposicionamento de fármacos
dc.relation.publisherversionhttp://www.pnas.org/content/111/48/16990.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectevolutionary cell biologypt_PT
dc.subjectcell biologypt_PT
dc.subjectadaptive evolutionpt_PT
dc.subjectrandom genetic driftpt_PT
dc.subjectcellular evolutionpt_PT
dc.titleEvolutionary cell biology: two origins, one objectivept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePerda de robustez como um princípio de reposicionamento de fármacos
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEBB-BIO%2F119006%2F2010/PT
oaire.citation.endPage16994pt_PT
oaire.citation.issue48pt_PT
oaire.citation.startPage16990pt_PT
oaire.citation.titleProceedings of the National Academy of Sciences of the United States of Americapt_PT
oaire.citation.volume111pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication38d12f4c-99a0-4d41-a564-c1a2b7f52311
relation.isProjectOfPublication.latestForDiscovery38d12f4c-99a0-4d41-a564-c1a2b7f52311

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