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Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes

2012-01-06Journal article Open access
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dc.contributor.authorGomes-Santos, Carina S S
dc.contributor.authorItoe, Maurice A
dc.contributor.authorAfonso, Cristina
dc.contributor.authorHenriques, Ricardo
dc.contributor.authorGardner, Rui
dc.contributor.authorSepúlveda, Nuno
dc.contributor.authorSimões, Pedro D
dc.contributor.authorRaquel, Helena
dc.contributor.authorAlmeida, António Paulo
dc.contributor.authorMoita, Luis F
dc.contributor.authorFrischknecht, Friedrich
dc.contributor.authorMota, Maria M
dc.date.accessioned2016-06-14T16:32:38Z
dc.date.available2016-06-14T16:32:38Z
dc.date.issued2012-01-06
dc.description.abstractPlasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (PTDC/SAU-GMG/100313/2008, PTDC/SAU-MII/69280/2006, PTDC/SAU-MII/78333/2006) and FCT fellowship: (SFRH/BD/15888/2005); Portuguese Ministry of Science; Federal German Ministry of education and Science (Biofuture); Human Frontier Science Program Fundação Luso-Americana para o Desenvolvimento; Chica and Heinz Schaller Foundation.pt_PT
dc.identifier.citationGomes-Santos CSS, Itoe MA, Afonso C, Henriques R, Gardner R, et al. (2012) Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes. PLoS ONE 7(1): e29408. doi:10.1371/journal.pone.0029408pt_PT
dc.identifier.doi10.1371/journal.pone.0029408pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/649
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relationIntervention strategies against malaria
dc.relationTowards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0029408pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectActin Cytoskeletonpt_PT
dc.subjectActinspt_PT
dc.subjectAnimalspt_PT
dc.subjectCells, Culturedpt_PT
dc.subjectGelsolinpt_PT
dc.subjectGreen Fluorescent Proteinspt_PT
dc.subjectHepatocytespt_PT
dc.subjectHost-Parasite Interactionspt_PT
dc.subjectHumanspt_PT
dc.subjectKineticspt_PT
dc.subjectLiverpt_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred BALB Cpt_PT
dc.subjectOrganisms, Genetically Modifiedpt_PT
dc.subjectPlasmodiumpt_PT
dc.subjectProtein Multimerizationpt_PT
dc.subjectTubulinpt_PT
dc.titleHighly dynamic host actin reorganization around developing Plasmodium inside hepatocytespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIntervention strategies against malaria
oaire.awardTitleTowards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/215281/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/242095/EU
oaire.citation.endPage9pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePloS onept_PT
oaire.citation.volume7pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationcca2dff2-5230-4749-bab0-bf1a5329f556
relation.isProjectOfPublicationae9ec4d8-bb5a-4faa-9619-be90d5764f73
relation.isProjectOfPublication.latestForDiscoverycca2dff2-5230-4749-bab0-bf1a5329f556

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