Tissue damage control in disease tolerance

Soares, Miguel P; Gozzelino, Raffaella; Weis, Sebastian

http://hdl.handle.net/10400.7/771

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Authors

Soares, Miguel P

Gozzelino, Raffaella

Weis, Sebastian

Abstract(s)

Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.

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Keywords

tissue damage control disease tolerance stress response damage response infection

URI

http://hdl.handle.net/10400.7/771

Citation

Miguel P. Soares, Raffaella Gozzelino, Sebastian Weis, Tissue damage control in disease tolerance, Trends in Immunology, Volume 35, Issue 10, 2014, Pages 483-494, ISSN 1471-4906, http://dx.doi.org/10.1016/j.it.2014.08.001. (http://www.sciencedirect.com/science/article/pii/S147149061400132X) Keywords: tissue damage control; disease tolerance; stress response; damage response; infection