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Tissue damage control in disease tolerance

2014-10Journal article Open access
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dc.contributor.authorSoares, Miguel P
dc.contributor.authorGozzelino, Raffaella
dc.contributor.authorWeis, Sebastian
dc.date.accessioned2017-06-22T18:06:03Z
dc.date.available2017-06-22T18:06:03Z
dc.date.issued2014-10
dc.descriptionThe deposited article is a prost-print version.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed by the main article, and it hasn't any supplementary materials associated.pt_PT
dc.description.abstractImmune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia grants: (PTDC/SAU-TOX/116627/2010, HMSP-ICT/0022/2010, SFRH/BPD/44256/2008); European Commission 7th Framework grant: (ERC-2011-AdG. 294709-DAMAGECONTROL); Deutsche Forschungsgemeinschaft grant: (DFG WE 4971/3-1).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiguel P. Soares, Raffaella Gozzelino, Sebastian Weis, Tissue damage control in disease tolerance, Trends in Immunology, Volume 35, Issue 10, 2014, Pages 483-494, ISSN 1471-4906, http://dx.doi.org/10.1016/j.it.2014.08.001. (http://www.sciencedirect.com/science/article/pii/S147149061400132X) Keywords: tissue damage control; disease tolerance; stress response; damage response; infectionpt_PT
dc.identifier.doi10.1016/j.it.2014.08.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/771
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFCT - HMSP-ICT/0022/2010pt_PT
dc.relationDeutsche Forschungsgemeinschaft - DFG WE 4971/3-1pt_PT
dc.relationTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S147149061400132X?via%3Dihubpt_PT
dc.subjecttissue damage controlpt_PT
dc.subjectdisease tolerancept_PT
dc.subjectstress responsept_PT
dc.subjectdamage responsept_PT
dc.subjectinfectionpt_PT
dc.titleTissue damage control in disease tolerancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-TOX%2F116627%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F44256%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294709/EU
oaire.citation.endPage494pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage483pt_PT
oaire.citation.titleTrends in Immunologypt_PT
oaire.citation.volume35pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication72d8fa6f-1215-4a61-bc70-515eef334d45
relation.isProjectOfPublication1727d823-6214-4844-ad0e-12a4d65e7e5e
relation.isProjectOfPublication370f9aad-c4ef-4e35-b754-edc840dc6b5e
relation.isProjectOfPublication.latestForDiscovery1727d823-6214-4844-ad0e-12a4d65e7e5e

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