dc.contributor.author	Trovoada, Maria Jesus
dc.contributor.author	Gonçalves, Lígia A.
dc.contributor.author	Marinho, Cláudio R. F.
dc.contributor.author	Turner, Louise
dc.contributor.author	Hviid, Lars
dc.contributor.author	Penha-Gonçalves, Carlos
dc.contributor.author	Gomes, M. Gabriela M.
dc.date.accessioned	2015-09-23T16:45:14Z
dc.date.available	2015-09-23T16:45:14Z
dc.date.issued	2014-02-10
dc.description	This deposit is composed by the main article plus the supplementary materials of the publication.
dc.description.abstract	After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants. The model was parameterized with data from Príncipe Island, West Africa, and applied to simulate two alternative transmission scenarios: one where control measures are continued to eventually drive the system to elimination; and another where the effort is interrupted after 6 years of its initiation and the system returns to the initial transmission potential. Population dynamics of parasite prevalence predict that in a few years infection levels return to the pre-control values, while the re-acquisition of the immune repertoire against PfEMP1 is slower, creating a window for increased severity. The model illustrates the consequences of loss of immune repertoire against PfEMP1 in a given setting and can be applied to other regions where similar data may be available.	pt_PT
dc.description.sponsorship	Portuguese Foundation for Science and Technology (FCT).	pt_PT
dc.identifier	10.1371/journal.pone.0088110
dc.identifier.citation	Bandeiras C, Trovoada MJ, Gonçalves LA, Marinho CRF, Turner L, Hviid L, et al. (2014) Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa. PLoS ONE 9(2): e88110. doi:10.1371/journal.pone.0088110	pt_PT
dc.identifier.doi	10.1371/journal.pone.0088110
dc.identifier.doi	10.1371/journal.pone.0088110
dc.identifier.uri	http://hdl.handle.net/10400.7/317
dc.language.iso	por	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	PLOS	pt_PT
dc.relation	Developing the Framework for an Epidemic Forecast Infrastructure
dc.relation	Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
dc.relation.publisherversion	http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088110	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Malaria Infection	pt_PT
dc.subject	Immunity	pt_PT
dc.title	Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Developing the Framework for an Epidemic Forecast Infrastructure
oaire.awardTitle	Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
oaire.awardURI	info:eu-repo/grantAgreement/EC/FP7/231807/EU
oaire.awardURI	info:eu-repo/grantAgreement/EC/FP7/242095/EU
oaire.citation.endPage	10	pt_PT
oaire.citation.issue	2	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	PLOS One	pt_PT
oaire.citation.volume	9	pt_PT
oaire.fundingStream	FP7
oaire.fundingStream	FP7
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.name	European Commission
project.funder.name	European Commission
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	120acf43-5f6e-4b79-a889-031b54eba6a7
relation.isProjectOfPublication	ae9ec4d8-bb5a-4faa-9619-be90d5764f73
relation.isProjectOfPublication.latestForDiscovery	120acf43-5f6e-4b79-a889-031b54eba6a7

Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa

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