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Centrioles: active players or passengers during mitosis?

2010-03-19Journal article Open access
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dc.contributor.authorDebec, Alain
dc.contributor.authorSullivan, William
dc.contributor.authorBettencourt-Dias, Monica
dc.date.accessioned2017-05-04T16:28:29Z
dc.date.available2017-05-04T16:28:29Z
dc.date.issued2010-03-19
dc.descriptionThere is no public supplementary material available.pt_PT
dc.description.abstractCentrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as "the organ for cell division". However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues.pt_PT
dc.description.sponsorshipThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDebec, A., Sullivan, W. & Bettencourt-Dias, M. Cell. Mol. Life Sci. (2010) 67: 2173. doi:10.1007/s00018-010-0323-9pt_PT
dc.identifier.doi10.1007/s00018-010-0323-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/750
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relationThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs00018-010-0323-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectCell Divisionpt_PT
dc.subjectCell Linept_PT
dc.subjectCentriolespt_PT
dc.subjectCentrosomept_PT
dc.subjectCiliapt_PT
dc.subjectDrosophilapt_PT
dc.subjectMicrotubulespt_PT
dc.subjectParthenogenesispt_PT
dc.subjectSpindle Apparatuspt_PT
dc.subjectMitosispt_PT
dc.titleCentrioles: active players or passengers during mitosis?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2194pt_PT
oaire.citation.issue13pt_PT
oaire.citation.startPage2173pt_PT
oaire.citation.titleCellular and Molecular Life Sciencespt_PT
oaire.citation.volume67pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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