Building the right centriole for each cell type

Loncarek, Jadranka; Bettencourt-Dias, Mónica

Publication

Building the right centriole for each cell type

2017-12-28Review

dc.contributor.author	Loncarek, Jadranka
dc.contributor.author	Bettencourt-Dias, Mónica
dc.date.accessioned	2018-02-07T11:55:42Z
dc.date.available	2018-06-01T00:30:08Z
dc.date.issued	2017-12-28
dc.description	The deposited article version is the publisher version, which is in a "Epub Ahead of Print” state at the moment of the deposit.	pt_PT
dc.description	This deposit is composed by the main article, and it hasn't any supplementary materials associated.	pt_PT
dc.description.abstract	The centriole is a multifunctional structure that organizes centrosomes and cilia and is important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole number and structure are associated with human diseases including cancer and ciliopathies. Discovery of the centriole dates back to the 19th century. However, recent advances in genetic and biochemical tools, development of high-resolution microscopy, and identification of centriole components have accelerated our understanding of its assembly, function, evolution, and its role in human disease. The centriole is an evolutionarily conserved structure built from highly conserved proteins and is present in all branches of the eukaryotic tree of life. However, centriole number, size, and organization varies among different organisms and even cell types within a single organism, reflecting its cell type-specialized functions. In this review, we provide an overview of our current understanding of centriole biogenesis and how variations around the same theme generate alternatives for centriole formation and function.	pt_PT
dc.description.sponsorship	Gulbenkian Foundation; European Research Council Consolidator Grant: (CoG683528); Fundaçao para a Ciencia e Tecnologia grant: (PTDC/BIM-ONC/6858/2014); National Institutes of Health; National Cancer Institute; Center for Cancer Research.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Building the right centriole for each cell type Jadranka Loncarek, Mónica Bettencourt-Dias J Cell Biol Dec 2017, jcb.201704093; DOI: 10.1083/jcb.201704093	pt_PT
dc.identifier.doi	10.1083/jcb.201704093	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/829
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Rockefeller University Press	pt_PT
dc.relation	CoG683528	pt_PT
dc.relation	"Length matters: Causes and consequences of centriole length deregulation in cancer"
dc.relation.publisherversion	http://jcb.rupress.org/content/early/2017/12/27/jcb.201704093	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	pt_PT
dc.subject	Centrioles	pt_PT
dc.subject	cell cycle	pt_PT
dc.subject	Cilia	pt_PT
dc.title	Building the right centriole for each cell type	pt_PT
dc.type	review
dspace.entity.type	Publication
oaire.awardTitle	"Length matters: Causes and consequences of centriole length deregulation in cancer"
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-ONC%2F6858%2F2014/PT
oaire.citation.title	Journal of Cell Biology	pt_PT
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.embargofct	The deposited article has 6 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo between 6 months after the date of the publication, and since the article is in "Epub Ahead of Print" it has a extended date of embargo, as a preventive measure.	pt_PT
rcaap.rights	embargoedAccess	pt_PT
rcaap.type	review	pt_PT
relation.isProjectOfPublication	8282ac35-73a1-4f8e-95da-dbed8651602e
relation.isProjectOfPublication.latestForDiscovery	8282ac35-73a1-4f8e-95da-dbed8651602e