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Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria

2015-11Journal article Restricted access
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dc.contributor.authorRommelaere, Samuel
dc.contributor.authorMillet, Virginie
dc.contributor.authorRihet, Pascal
dc.contributor.authorAtwell, Scott
dc.contributor.authorHelfer, Emmanuèle
dc.contributor.authorChasson, Lionel
dc.contributor.authorBeaumont, Carole
dc.contributor.authorChimini, Giovanna
dc.contributor.authorSambo, Maria do Rosário
dc.contributor.authorViallat, Annie
dc.contributor.authorPenha-Gonçalves, Carlos
dc.contributor.authorGalland, Franck
dc.contributor.authorNaquet, Philippe
dc.date.accessioned2018-05-24T10:48:01Z
dc.date.available2018-05-24T10:48:01Z
dc.date.issued2015-11
dc.descriptionThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0002944015004393?via%3Dihub#ack0010pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed by the main article plus the supplementary materials of the publication.pt_PT
dc.description.abstractTissue pantetheinase, encoded by the VNN1 gene, regulates response to stress, and previous studies have shown that VNN genes contribute to the susceptibility to malaria. Herein, we evaluated the role of pantetheinase on erythrocyte homeostasis and on the development of malaria in patients and in a new mouse model of pantetheinase insufficiency. Patients with cerebral malaria have significantly reduced levels of serum pantetheinase activity (PA). In mouse, we show that a reduction in serum PA predisposes to severe malaria, including cerebral malaria and severe anemia. Therefore, scoring pantetheinase in serum may serve as a severity marker in malaria infection. This disease triggers an acute stress in erythrocytes, which enhances cytoadherence and hemolysis. We speculated that serum pantetheinase might contribute to erythrocyte resistance to stress under homeostatic conditions. We show that mutant mice with a reduced serum PA are anemic and prone to phenylhydrazine-induced anemia. A cytofluorometric and spectroscopic analysis documented an increased frequency of erythrocytes with an autofluorescent aging phenotype. This is associated with an enhanced oxidative stress and shear stress-induced hemolysis. Red blood cell transfer and bone marrow chimera experiments show that the aging phenotype is not cell intrinsic but conferred by the environment, leading to a shortening of red blood cell half-life. Therefore, serum pantetheinase level regulates erythrocyte life span and modulates the risk of developing complicated malaria.pt_PT
dc.description.sponsorshipThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSamuel Rommelaere, Virginie Millet, Pascal Rihet, Scott Atwell, Emmanuèle Helfer, Lionel Chasson, Carole Beaumont, Giovanna Chimini, Maria do Rosário Sambo, Annie Viallat, Carlos Penha-Gonçalves, Franck Galland, Philippe Naquet, Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria, The American Journal of Pathology, Volume 185, Issue 11, 2015, Pages 3039-3052, ISSN 0002-9440, https://doi.org/10.1016/j.ajpath.2015.07.011. (http://www.sciencedirect.com/science/article/pii/S0002944015004393)pt_PT
dc.identifier.doi10.1016/j.ajpath.2015.07.011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/881
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0002944015004393?via%3Dihubpt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectAmidohydrolasespt_PT
dc.subjectAnemiapt_PT
dc.subjectAnimalspt_PT
dc.subjectChildpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectDisease Models, Animalpt_PT
dc.subjectDisease Susceptibilitypt_PT
dc.subjectErythrocytespt_PT
dc.subjectFemalept_PT
dc.subjectGPI-Linked Proteinspt_PT
dc.subjectHomeostasispt_PT
dc.subjectHumanspt_PT
dc.subjectInfantpt_PT
dc.subjectMalariapt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectYoung Adultpt_PT
dc.titleSerum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malariapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3052pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage3039pt_PT
oaire.citation.titleAmerican Journal of Pathologypt_PT
oaire.citation.volume185pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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