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IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition

2016-09Journal article Restricted access
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dc.contributor.authorOruc, Zeliha
dc.contributor.authorOblet, Christelle
dc.contributor.authorBoumediene, Ahmed
dc.contributor.authorDruilhe, Anne
dc.contributor.authorPascal, Virginie
dc.contributor.authorLe Rumeur, Elisabeth
dc.contributor.authorCuvillier, Armelle
dc.contributor.authorEl Hamel, Chahrazed
dc.contributor.authorLecardeur, Sandrine
dc.contributor.authorLeanderson, Tomas
dc.contributor.authorMorelle, Willy
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorAldigier, Jean-Claude
dc.contributor.authorCogné, Michel
dc.date.accessioned2018-03-05T15:31:49Z
dc.date.available2018-03-05T15:31:49Z
dc.date.issued2016-09
dc.descriptionThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004660/pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionFurther funders are not indicated in the document.pt_PT
dc.description.abstractIgA1 mesangial deposition is the hallmark of IgA nephropathy and Henoch-Schönlein purpura, the onset of which often follows infections. Deposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but with no information concerning the influence of the IgA repertoire or the link between immune stimuli and IgA structure. We explored these issues in the α1KI mouse model, which produces polyclonal human IgA1 prone to mesangial deposition. Compared with mice challenged by a conventional environment, mice in a specific pathogen-free environment had less IgA deposition. However, serum IgA of specific pathogen-free mice showed more galactosylation and much lower polymerization. Notably, wild-type, α1KI, and even J chain-deficient mice showed increased polymeric serum IgA on exposure to pathogens. Strict germfree conditions delayed but did not completely prevent deposition; mice housed in these conditions had very low serum IgA levels and produced essentially monomeric IgA. Finally, comparing monoclonal IgA1 that had different variable regions and mesangial deposition patterns indicated that, independently of glycosylation and polymerization, deposition might also depend on IgA carrying specific variable domains. Together with IgA quantities and constant region post-translational modifications, repertoire changes during immune responses might, thus, modulate IgA propensity to deposition. These IgA features are not associated with circulating immune complexes and C3 deposition and are more pertinent to an initial IgA deposition step preceding overt clinical symptoms in patients.pt_PT
dc.description.sponsorshipAgence Nationale de la Recherche; Ligue Nationale contre le Cancer; Conseil Régional du Limousin; European Community grants: (Fonds Européens de Développement Régional); Région Nord-Pas de Calais (France); Université des Sciences et Technologies de Lille 1.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition Zeliha Oruc, Christelle Oblet, Ahmed Boumediene, Anne Druilhe, Virginie Pascal, Elisabeth Le Rumeur, Armelle Cuvillier, Chahrazed El Hamel, Sandrine Lecardeur, Tomas Leanderson, Willy Morelle, Jocelyne Demengeot, Jean-Claude Aldigier, and Michel Cogné JASN September 2016 27: 2748-2761; published ahead of print January 29, 2016, doi:10.1681/ASN.2015080911pt_PT
dc.identifier.doi10.1681/ASN.2015080911pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/846
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society of Nephrologypt_PT
dc.relation.publisherversionhttp://jasn.asnjournals.org/content/27/9/2748pt_PT
dc.subjectIgA nephropathypt_PT
dc.subjectIgA depositionpt_PT
dc.subjectIgApt_PT
dc.subjecttransgenic mousept_PT
dc.subjectImmunology and pathologypt_PT
dc.titleIgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Depositionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2761pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2748pt_PT
oaire.citation.titleJournal of the American Society of Nephrologypt_PT
oaire.citation.volume27pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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