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Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos

2013-06-10Journal article Open access
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dc.contributor.authorJurberg, Arnon Dias
dc.contributor.authorAires, Rita
dc.contributor.authorVarela-Lasheras, Irma
dc.contributor.authorNóvoa, Ana
dc.contributor.authorMallo, Moisés
dc.date.accessioned2016-06-29T09:38:23Z
dc.date.available2016-06-29T09:38:23Z
dc.date.issued2013-06-10
dc.description.abstractThe vertebrate body is made by progressive addition of new tissue from progenitors at the posterior embryonic end. Axial extension involves different mechanisms that produce internal organs in the trunk but not in the tail. We show that Gdf11 signaling is a major coordinator of the trunk-to-tail transition. Without Gdf11 signaling, the switch from trunk to tail is significantly delayed, and its premature activation brings the hindlimbs and cloaca next to the forelimbs, leaving extremely short trunks. Gdf11 activity includes activation of Isl1 to promote formation of the hindlimbs and cloaca-associated mesoderm as the most posterior derivatives of lateral mesoderm progenitors. Gdf11 also coordinates reallocation of bipotent neuromesodermal progenitors from the anterior primitive streak to the tail bud, in part by reducing the retinoic acid available to the progenitors. Our findings provide a perspective to understand the evolution of the vertebrate body plan.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (PTDC/BIA-BCM/110638/2009, PTDC/SAU-BID/110640/2009); FCT PhD fellowships: (SFRH/BD/33562/2008, SFRH/BD/51876/2012, SFRH/BD/51879/2012).pt_PT
dc.identifier.citationArnon Dias Jurberg, Rita Aires, Irma Varela-Lasheras, Ana Nóvoa, Moisés Mallo, Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos, Developmental Cell, Volume 25, Issue 5, 10 June 2013, Pages 451-462, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2013.05.009. (http://www.sciencedirect.com/science/article/pii/S1534580713002839)pt_PT
dc.identifier.doi10.1016/j.devcel.2013.05.009pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/671
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1534580713002839pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAnimals, Newbornpt_PT
dc.subjectBase Sequencept_PT
dc.subjectBone Morphogenetic Proteinspt_PT
dc.subjectBone and Bonespt_PT
dc.subjectGrowth Differentiation Factorspt_PT
dc.subjectLIM-Homeodomain Proteinspt_PT
dc.subjectMesodermpt_PT
dc.subjectMicept_PT
dc.subjectMice, Transgenicpt_PT
dc.subjectMolecular Sequence Datapt_PT
dc.subjectPhenotypept_PT
dc.subjectProtein-Serine-Threonine Kinasespt_PT
dc.subjectReceptors, Transforming Growth Factor betapt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectStem Cellspt_PT
dc.subjectTailpt_PT
dc.subjectTranscription Factorspt_PT
dc.subjectTretinoinpt_PT
dc.subjectBody Patterningpt_PT
dc.subjectGene Expression Regulation, Developmentalpt_PT
dc.titleSwitching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryospt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage462pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage451pt_PT
oaire.citation.titleDevelopmental Cellpt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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