Temporal control of epigenetic centromere specification

Valente, Luis P; Silva, Mariana C C; Jansen, Lars E T

Publication

Temporal control of epigenetic centromere specification

2012-07Journal article

dc.contributor.author	Valente, Luis P
dc.contributor.author	Silva, Mariana C C
dc.contributor.author	Jansen, Lars E T
dc.date.accessioned	2016-05-24T12:10:01Z
dc.date.available	2016-05-24T12:10:01Z
dc.date.issued	2012-07
dc.description.abstract	All living organisms require accurate mechanisms to faithfully inherit their genetic material during cell division. The centromere is a unique locus on each chromosome that supports a multiprotein structure called the kinetochore. During mitosis, the kinetochore is responsible for connecting chromosomes to spindle microtubules, allowing faithful segregation of the duplicated genome. In most organisms, centromere position and function is not defined by the local DNA sequence context but rather by an epigenetic chromatin-based mechanism. Centromere protein A (CENP-A) is central to this process, as chromatin assembled from this histone H3 variant is essential for assembly of the centromere complex, as well as for its epigenetic maintenance. As a major determinant of centromere function, CENP-A assembly requires tight control, both in its specificity for the centromere and in timing of assembly. In the last few years, there have been several new insights into the molecular mechanism that allow this process to occur. We will review these here and discuss the general implications of the mechanism of cell cycle coupling of centromere inheritance.	pt_PT
dc.description.sponsorship	FCT fellowships: (SFRH/BPD/69115/2010, SFRH/BD/33219/2007); FCT grants: (BIA-BCM/100557/2008, BIA-PRO/100537/2008);Fundação Calouste Gulbenkian; European Commission FP7 programme; EMBO installation grant.	pt_PT
dc.identifier.citation	Valente, L. P., Silva, M. C. C., Jansen, L. E. T. (2012). Temporal control of epigenetic centromere specification. Chromosome Res, 20(5), 481–492.	pt_PT
dc.identifier.doi	10.1007/s10577-012-9291-2	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/617
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Springer Verlag	pt_PT
dc.relation.publisherversion	http://link.springer.com/article/10.1007%2Fs10577-012-9291-2	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Animals	pt_PT
dc.subject	Autoantigens	pt_PT
dc.subject	Base Sequence	pt_PT
dc.subject	Cell Cycle Checkpoints	pt_PT
dc.subject	Centromere	pt_PT
dc.subject	Chromatin Assembly and Disassembly	pt_PT
dc.subject	Chromosomal Proteins, Non-Histone	pt_PT
dc.subject	Chromosome Segregation	pt_PT
dc.subject	Fungi	pt_PT
dc.subject	Histones	pt_PT
dc.subject	Humans	pt_PT
dc.subject	Inheritance Patterns	pt_PT
dc.subject	Models, Genetic	pt_PT
dc.subject	Protein Interaction Mapping	pt_PT
dc.subject	Substrate Specificity	pt_PT
dc.subject	Epigenesis, Genetic	pt_PT
dc.title	Temporal control of epigenetic centromere specification	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	492	pt_PT
oaire.citation.issue	5	pt_PT
oaire.citation.startPage	481	pt_PT
oaire.citation.title	Chromosome research	pt_PT
oaire.citation.volume	20	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT