dc.contributor.author	Moura de Sousa, Jorge A.
dc.contributor.author	Alpedrinha, João
dc.contributor.author	Campos, Paulo R.A.
dc.contributor.author	Gordo, Isabel
dc.date.accessioned	2016-08-29T12:16:55Z
dc.date.available	2016-08-29T12:16:55Z
dc.date.issued	2016-08-02
dc.description.abstract	One of the simplest models of adaptation to a new environment is Fisher's Geometric Model (FGM), in which populations move on a multidimensional landscape defined by the traits under selection. The predictions of this model have been found to be consistent with current observations of patterns of fitness increase in experimentally evolved populations. Recent studies investigated the dynamics of allele frequency change along adaptation of microbes to simple laboratory conditions and unveiled a dramatic pattern of competition between cohorts of mutations, i.e., multiple mutations simultaneously segregating and ultimately reaching fixation. Here, using simulations, we study the dynamics of phenotypic and genetic change as asexual populations under clonal interference climb a Fisherian landscape, and ask about the conditions under which FGM can display the simultaneous increase and fixation of multiple mutations-mutation cohorts-along the adaptive walk. We find that FGM under clonal interference, and with varying levels of pleiotropy, can reproduce the experimentally observed competition between different cohorts of mutations, some of which have a high probability of fixation along the adaptive walk. Overall, our results show that the surprising dynamics of mutation cohorts recently observed during experimental adaptation of microbial populations can be expected under one of the oldest and simplest theoretical models of adaptation-FGM.	pt_PT
dc.description.sponsorship	Fundação para a Ciência e a Tecnologia; LAO/ITQB; Conselho Nacional de Desenvolvimento CientÌfico e Tecnologico (CNPq).	pt_PT
dc.identifier.citation	Moura de Sousa et al. (2016), Competition and fixation of cohorts of adaptive mutations under Fisher geometri- cal model. PeerJ 4:e2256; DOI 10.7717/peerj.2256	pt_PT
dc.identifier.doi	10.7717/peerj.2256	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/695
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	PeerJ	pt_PT
dc.relation	Microbial adaptation within ecosystems
dc.relation	Adaptation of commensal bacteria to the mammalian gut
dc.relation	EXPLORING ADAPTATION BEYOND FITNESS PEAKS
dc.relation.publisherversion	https://peerj.com/articles/2256/	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Fisher Geometric Model	pt_PT
dc.subject	Clonal interference	pt_PT
dc.subject	Genetic hitchiking	pt_PT
dc.subject	Natural selection	pt_PT
dc.title	Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Microbial adaptation within ecosystems
oaire.awardTitle	Adaptation of commensal bacteria to the mammalian gut
oaire.awardTitle	EXPLORING ADAPTATION BEYOND FITNESS PEAKS
oaire.awardURI	info:eu-repo/grantAgreement/EC/FP7/260421/EU
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-EVF%2F118075%2F2010/PT
oaire.awardURI	info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F89151%2F2012/PT
oaire.citation.endPage	17	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	PeerJ	pt_PT
oaire.citation.volume	4	pt_PT
oaire.fundingStream	FP7
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	European Commission
project.funder.name	Fundação para a Ciência e a Tecnologia
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	1f01df05-f8af-4e76-8dec-0fc6237b41fd
relation.isProjectOfPublication	8a096e46-5521-429a-b9e8-8a7901fe8b30
relation.isProjectOfPublication	85cd72e1-1c33-480c-ae77-f1effb2ee9cc
relation.isProjectOfPublication.latestForDiscovery	1f01df05-f8af-4e76-8dec-0fc6237b41fd

Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model

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