Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Durão, Paulo; Balbontín, Roberto; Gordo, Isabel

http://hdl.handle.net/10400.7/874

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Authors

Durão, Paulo

Balbontín, Roberto

Gordo, Isabel

Abstract(s)

Antibiotics target essential cellular functions but bacteria can become resistant by acquiring either exogenous resistance genes or chromosomal mutations. Resistance mutations typically occur in genes encoding essential functions; these mutations are therefore generally detrimental in the absence of drugs. However, bacteria can reduce this handicap by acquiring additional mutations, known as compensatory mutations. Genetic interactions (epistasis) either with the background or between resistances (in multiresistant bacteria) dramatically affect the fitness cost of antibiotic resistance and its compensation, therefore shaping dissemination of antibiotic resistance mutations. This Review summarizes current knowledge on the evolutionary mechanisms influencing maintenance of resistance mediated by chromosomal mutations, focusing on their fitness cost, compensatory evolution, epistasis, and the effect of the environment on these processes.

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The deposited review is a post-print version and has been submitted to peer review.
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Keywords

antibiotic evolution fitness costs compensation epistasis multidrug resistance

URI

http://hdl.handle.net/10400.7/874

Citation

Paulo Durão, Roberto Balbontín, Isabel Gordo, Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance, Trends in Microbiology,2018,https://doi.org/10.1016/j.tim.2018.01.005. (http://www.sciencedirect.com/science/article/pii/S0966842X18300179)