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Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

2018-02Review Open access
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dc.contributor.authorDurão, Paulo
dc.contributor.authorBalbontín, Roberto
dc.contributor.authorGordo, Isabel
dc.date.accessioned2018-05-18T15:55:27Z
dc.date.available2019-02-01T01:30:09Z
dc.date.issued2018-02
dc.descriptionThe deposited review is a post-print version and has been submitted to peer review.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed by the review, and it hasn't any supplementary materials associated.pt_PT
dc.descriptionThe publication deposited was in a state of Epub Ahead of Print, at the time when the upload was made.pt_PT
dc.description.abstractAntibiotics target essential cellular functions but bacteria can become resistant by acquiring either exogenous resistance genes or chromosomal mutations. Resistance mutations typically occur in genes encoding essential functions; these mutations are therefore generally detrimental in the absence of drugs. However, bacteria can reduce this handicap by acquiring additional mutations, known as compensatory mutations. Genetic interactions (epistasis) either with the background or between resistances (in multiresistant bacteria) dramatically affect the fitness cost of antibiotic resistance and its compensation, therefore shaping dissemination of antibiotic resistance mutations. This Review summarizes current knowledge on the evolutionary mechanisms influencing maintenance of resistance mediated by chromosomal mutations, focusing on their fitness cost, compensatory evolution, epistasis, and the effect of the environment on these processes.pt_PT
dc.description.sponsorshipPD and RB were supported by Fundação para a Ciência e Tecnologia (FCT), fellowships SFRH/BPD/118474/2016 and SFRH/BPD/109517/2015, respectively. Current research is supported by project JPIAMR/0001/2016-ERA NET and ONEIDA project (LISBOA-01-0145-FEDER-016417) co-funded by FEEI – ‘Fundos Europeus Estruturais e de Investimento’ from ‘Programa Operacional Regional Lisboa 2020’, and by national funds from FCT – ‘Fundação para a Ciência e a Tecnologia’.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationPaulo Durão, Roberto Balbontín, Isabel Gordo, Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance, Trends in Microbiology,2018,https://doi.org/10.1016/j.tim.2018.01.005. (http://www.sciencedirect.com/science/article/pii/S0966842X18300179)pt_PT
dc.identifier.doi10.1016/j.tim.2018.01.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/874
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationJPIAMR/0001/2016-ERA NETpt_PT
dc.relationMaintenance of Antibiotic Resistance in the Mice Gut
dc.relationPhenotypic and molecular dissection of the epistasis between antibiotic resistance mutations in <i>Escherichia coli</i>
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0966842X18300179?via%3Dihubpt_PT
dc.subjectantibioticpt_PT
dc.subjectevolutionpt_PT
dc.subjectfitness costspt_PT
dc.subjectcompensationpt_PT
dc.subjectepistasispt_PT
dc.subjectmultidrug resistancept_PT
dc.titleEvolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistancept_PT
dc.typereview
dspace.entity.typePublication
oaire.awardTitleMaintenance of Antibiotic Resistance in the Mice Gut
oaire.awardTitlePhenotypic and molecular dissection of the epistasis between antibiotic resistance mutations in <i>Escherichia coli</i>
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F118474%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F109517%2F2015/PT
oaire.citation.endPage28pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleTrends in Microbiologypt_PT
oaire.fundingStreamOE
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctThe deposited review has 12 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo of 12 months of duration since the released date of the publication.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typereviewpt_PT
relation.isProjectOfPublication402adb0c-a306-4c55-9d91-d19ddaf2cce7
relation.isProjectOfPublication862ca18e-6a67-4e76-9a66-6bd5c2cf0d42
relation.isProjectOfPublication.latestForDiscovery402adb0c-a306-4c55-9d91-d19ddaf2cce7

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