Effect of celastrol on bone structure and mechanics in arthritic rats

Cascão, Rita; Vidal, Bruno; Jalmari Finnilä, Mikko Arttu; Lopes, Inês Pascoal; Teixeira, Rui Lourenço; Saarakkala, Simo; Moita, Luis Ferreira; Fonseca, João Eurico

http://hdl.handle.net/10400.7/790

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Authors

Cascão, Rita

Vidal, Bruno

Jalmari Finnilä, Mikko Arttu

Lopes, Inês Pascoal

Teixeira, Rui Lourenço

Saarakkala, Simo

Moita, Luis Ferreira

Fonseca, João Eurico

Abstract(s)

Rheumatoid arthritis (RA) is characterised by chronic inflammation leading to articular bone and cartilage damage. Despite recent progress in RA management, adverse effects, lack of efficacy and economic barriers to treatment access still limit therapeutic success. Therefore, safer and less expensive treatments that control inflammation and bone resorption are needed. We have previously shown that celastrol is a candidate for RA treatment. We have observed that it inhibits both interleukin (IL)-1β and tumor necrosis factor (TNF) in vitro, and that it has anti-inflammatory properties and ability to decrease synovial CD68+ macrophages in vivo. Herein our goal was to evaluate the effect of celastrol in local and systemic bone loss.

Keywords

Adjuvant-induced arthritis Bone loss Celastrol Inflammation Rheumatoid arthritis

URI

http://hdl.handle.net/10400.7/790

Citation

Cascão R, Vidal B, Jalmari Finnilä MA, et al. Effect of celastrol on bone structure and mechanics in arthritic rats. RMD Open 2017;3:e000438. doi:10.1136/ rmdopen-2017-000438