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Effect of celastrol on bone structure and mechanics in arthritic rats

2017-09-14Journal article Open access
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dc.contributor.authorCascão, Rita
dc.contributor.authorVidal, Bruno
dc.contributor.authorJalmari Finnilä, Mikko Arttu
dc.contributor.authorLopes, Inês Pascoal
dc.contributor.authorTeixeira, Rui Lourenço
dc.contributor.authorSaarakkala, Simo
dc.contributor.authorMoita, Luis Ferreira
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2017-10-23T14:53:20Z
dc.date.available2017-10-23T14:53:20Z
dc.date.issued2017-09-14
dc.description.abstractRheumatoid arthritis (RA) is characterised by chronic inflammation leading to articular bone and cartilage damage. Despite recent progress in RA management, adverse effects, lack of efficacy and economic barriers to treatment access still limit therapeutic success. Therefore, safer and less expensive treatments that control inflammation and bone resorption are needed. We have previously shown that celastrol is a candidate for RA treatment. We have observed that it inhibits both interleukin (IL)-1β and tumor necrosis factor (TNF) in vitro, and that it has anti-inflammatory properties and ability to decrease synovial CD68+ macrophages in vivo. Herein our goal was to evaluate the effect of celastrol in local and systemic bone loss.pt_PT
dc.description.sponsorshipThere are no funders and sponsors indicated explicitly in the document. There is no public supplementary material available.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCascão R, Vidal B, Jalmari Finnilä MA, et al. Effect of celastrol on bone structure and mechanics in arthritic rats. RMD Open 2017;3:e000438. doi:10.1136/ rmdopen-2017-000438pt_PT
dc.identifier.doi10.1136/rmdopen-2017-000438pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/790
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relationThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.relation.publisherversionhttp://rmdopen.bmj.com/content/3/2/e000438pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAdjuvant-induced arthritispt_PT
dc.subjectBone losspt_PT
dc.subjectCelastrolpt_PT
dc.subjectInflammationpt_PT
dc.subjectRheumatoid arthritispt_PT
dc.titleEffect of celastrol on bone structure and mechanics in arthritic ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleRMD Openpt_PT
oaire.citation.volume3pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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