Browsing by Issue Date, starting with "2012-10-14"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cellsPublication . Costa, Nuno; Pires, Ana E.; Gabriel, Ana M.; Goulart, Luiz F.; Pereira, Clara; Leal, Bárbara; Queiros, Ana C.; Chaara, Wahiba; Moraes-Fontes, Maria F.; Vasconcelos, Carlos; Ferreira, Carlos; Martins, Jorge; Bastos, Marina; Santos, Maria J.; Pereira, Maria A.; Martins, Berta; Lima, Margarida; João, Cristina; Six, Adrien; Demengeot, Jocelyne; Fesel, ConstantinIntravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Foxp3+ regulatory T-cells (Tregs) reflected by lower CD25 surface density.