Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells

Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Foxp3+ regulatory T-cells (Tregs) reflected by lower CD25 surface density.

Keywords

Adult Forkhead Transcription Factors Humans Interleukin-2 Receptor alpha Subunit Longitudinal Studies Lupus Erythematosus, Systemic Middle Aged Receptors, Antigen, T-Cell, alpha-beta T-Lymphocyte Subsets T-Lymphocytes, Regulatory Young Adult Immunoglobulins, Intravenous