Evolution: Tracing the origins of centrioles, cilia, and flagella

Carvalho-Santos, Zita; Azimzadeh, Juliette; Pereira-Leal, José B; Bettencourt-Dias, Mónica

http://hdl.handle.net/10400.7/837

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Authors

Carvalho-Santos, Zita

Azimzadeh, Juliette

Pereira-Leal, José B

Bettencourt-Dias, Mónica

Abstract(s)

Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral structures; they are present in all major eukaryotic groups. Despite the conservation of their core structure, there is variability in their architecture, function, and biogenesis. Recent genomic and functional studies have provided insight into the evolution of the structure and function of these organelles.

Description

This deposit is composed by the main article plus the supplementary materials of the publication.

Keywords

Animals Centrioles Cilia Flagella Humans Phylogeny

URI

http://hdl.handle.net/10400.7/837

Citation

Tracing the origins of centrioles, cilia, and flagella Zita Carvalho-Santos, Juliette Azimzadeh, José. B. Pereira-Leal, Mónica Bettencourt-Dias J Cell Biol Jul 2011, 194 (2) 165-175; DOI: 10.1083/jcb.201011152