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A structural road map to unveil basal body composition and assembly
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Orientador(es)
Resumo(s)
The Basal Body (BB) acts as the template for the axoneme, the microtubule‐basedstructure of cilia and flagella. Although several proteins were recently implicatedin both centriole and BB assembly and function, their molecular mechanisms are stillpoorly characterized. In this issue of The EMBO journal, Li and coworkersdescribe for the first time the near‐native structure of the BB at 33 Åresolution obtained by Cryo‐Electron Microscopy analysis of wild‐type (WT) isolatedChlamydomonas BBs. They identified several uncharacterized non‐tubulinstructures and variations along the length of the BB, which likely reflect thebinding and function of numerous macromolecular complexes. These complexes areexpected to define BB intrinsic properties, such as its characteristic structure andstability. Similarly to the high‐resolution structures of ribosome and nuclear porecomplexes, this study will undoubtedly contribute towards the future analysis ofcentriole and BB biogenesis, maintenance and function.
Descrição
The deposited article is a post-print version and has been submitted to peer review.
This publication hasn't any creative commons license associated.
There is no public supplementary material available.
This publication hasn't any creative commons license associated.
There is no public supplementary material available.
Palavras-chave
Animals Cilia Microtubules Basal Body
Contexto Educativo
Citação
Swadhin C Jana, Pedro Machado, Mónica Bettencourt‐Dias (2012). A structural road map to unveil basal body composition and assembly. EMBO J. 31(3):519-21. DOI 10.1038/emboj.2011.474